camptothecin20(s)opropionate

CZ-48 is a DNA topoisomerase inhibitor.

20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo).

20 (S)-Hydroxy Prednisolone-d4 is a deuterated compound of 20 (S)-Hydroxy Prednisolone. 20 (S)-Hydroxy Prednisolone has a CAS number of 2299-46-9.

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.

20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial cells(HUVEC) and has anti-angiogenesis activities.

20(S),24(R)-Ocotillol, a natural product, is characterized by a unique structure featuring specific stereoisomers denoted by (S) at carbon 20 and (R) at carbon 24.

Adam-20-S is a potent inhibitor of glucosinolate sulfatase, with an IC50 of 9.04 μg mL. This compound disrupts glucosinolate metabolism, enhancing the production of toxic isothiocyanates in P. xylostella [1].