Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhi

Catestatin acetate is a non-competitive antagonist of nAChR and inhibits catecholamine release. Catestatin acetate regulates cardiac function and blood pressure.

Catestatin TFA, a 21-amino acid residue peptide, exhibits both cationic and hydrophobic properties. This endogenous peptide plays a crucial role in regulating cardiac function and blood pressure. It functions as a non-competitive nicotinic antagonist by interacting with nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release.