cbp/p300 in 3

CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.

(2S)-1-O-p-coumaroyl-2-O-acetyl-3-O-β-D-glucopyranosylglycerol is a useful research compound for many research applications, including the fields of chemistry and life sciences, among others.

3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).

PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.

Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside, an acylated kaempferol glucoside, can be extracted from the leaves of O. dentata and functions as a repellent to the fouling organism, the blue mussel M. edulis [1].

3''-p-Coumaroylprunin is a useful organic compound for research related to life sciences. The catalog number is T124102 and the CAS number is 84813-73-0.

3-beta-O-(trans-p-Coumaroyl)maslinic acid is a DNA polymerase B inhibitor. It shows antimicrobial activity on Gram-positive bacteria and yeasts.

Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.

Substance P (3-11), an SP fragment peptide capable of crossing the blood-brain barrier (BBB), induces contraction in guinea pig ileum and facilitates chemotaxis in human monocytes [1] [2] [5].

1,8-Dihydroxy-p-menth-3-en-2-one is a natural product for research related to life sciences. The catalog number is TN5870 and the CAS number is 1392224-56-4.

Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside, a natural compound, can be extracted from grapes [1].

3-beta-O-(trans-p-Coumaroyl)maslinic acid shows antimicrobial activity on Gram-positive bacteria and yeasts.

3-Hydroxy-p-menth-1-en-6-one is a natural product for research related to life sciences. The catalog number is TN5861 and the CAS number is 61570-82-9.

CBP/p300-IN-15 (compound 13a) is a potent inhibitor of p300 (IC50: 2.5 nM) and CBP (IC50: 28.0 nM). p300-IN-15 inhibits OVCAR-3 cells (EC50: 0.865 μM) and A2780 cells (EC50. 2.71 μM). 2.71 μM). CBP/p300-IN-15 can be used to study ovarian cancer.

3'-Deoxy-3'-fluoro-xylo-N6-(p-methoxybenzyl)adenosine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside, Fluoro-modified nucleoside.

CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP.

Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside (Quercetin 3-O-beta-(6''-p-coumaroyl)glucopyranosyl(1->2)-alpha-L-rhamnopyranoside) is a compound extracted from the leaves of Ginkgo biloba. Quercetin 3-o - -(6 '-p-coumaryl) glucopyranose (1->2) -α-L-rhamnoside has antioxidant properties.

Ir[p-F(t-Bu)-ppy]3 is a useful organic compound for research related to life sciences and the catalog number is T64556.

CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).

p-Phenetidine, 3-methoxy- is a bioactive chemical.

CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).

2-Amino-6-chloropurine-9-beta-D-(2'-deoxy-3',5'-di-(O-p-toluoyl))riboside is a 2'-Deoxy nucleoside; Halo-nucleoside.

CBP/p300-IN-19 hydrochloride is a selective and potent inhibitor of p300/CBP HAT, capable of acting on p300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 2.2 μM), PCAF (IC50>100 μM), Myst3 (IC50>100 μM). CBP/p300-IN-19 hydrochloride has antitumor effects.

3'-beta-C-Methyl-N6-(p-methoxybenzyl)adenosine is a Nucleoside Derivative - 3'-Modified nucleoside, 6-Modified purine nucleoside.

P-gp Inhibitor 3, an effective P-glycoprotein (P-gp) inhibitor, activates P-gp ATPase to inhibit P-gp's efflux function. It demonstrates a relatively stronger multidrug resistance (MDR) reversal ability, thereby enhancing the anti-tumor efficacy of Paclitaxel.

3-beta-O-(cis-p-Coumaroyl)corosolic acid is a useful organic compound for research related to life sciences and the catalog number is T125734.

Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.

Phthalimide, N-(3-(p-aminophenoxy)propyl)-, methanesulfonate is a bioactive chemical.

5’-O-DMTr-2’-OMe-5MeU-P-methyl phosphonamidite; 5’-O-DMTr-2’-O-methyl-5-methyluridine-3’-O-(P-methyl-N,N-diisopropylamino) phosphonamidite is a useful organic compound for research related to life sciences and the catalog number is TNU1620.

3,5,7-Trihydroxy-p-menth-1-en-6-one, 5-Tigloyl, 3 is a useful organic compound for research related to life sciences and the catalog number is T130192.

4-(p-Biphenylyl)-3-hydroxybutyric acid is a useful organic compound for research related to life sciences and the catalog number is T124405.

3-O-(p-Hydroxybenzoyl)serratriol is a natural product for research related to life sciences. The catalog number is TN6289 and the CAS number is 1448534-93-7.

Methanesulfonato(tri-t-butylphosphino)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67261.

Ammonium, (3-(p-triethylammoniophenyl)propyl)triethyl-, diiodide is a bioactive chemical.

Phthalimide, N-(5-(p-aminophenoxy)pentyl)-3-nitro- is a bioactive chemical.

3-O-p-Coumaroyloleanolic acid is a natural product for research related to life sciences. The catalog number is TN2976 and the CAS number is 151334-06-4.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-2-O-acetyl-5-(O-p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1038.

(S,E)-2-Methyl-6-(p-tolyl)hept-3-en-2-ol is a useful organic compound for research related to life sciences and the catalog number is T125520.

3-(p-Tolyl)-1H-pyrazole is a useful organic compound for research related to life sciences. The catalog number is T67474 and the CAS number is 59843-75-3.

Ammonium, (3-(p-trimethylammoniophenyl)propyl)trimethyl-, diiodide is a bioactive chemical.

3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin is a natural product for research related to life sciences. The catalog number is TN2871 and the CAS number is 349545-02-4.

Nucleoside Derivatives - 3’-Modified nucleoside, Azido-nucleosides

CBP/p300-IN-10, a potent inhibitor targeting histone acetyltransferase enzymes EP300 and CREBBP, exhibits IC50 values of 26 nM and 39 nM, respectively. This compound shows potential for anticancer research applications.

5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite, a purine nucleoside analog, exhibits extensive antitumor activity specific to indolent lymphoid malignancies. Its anticancer effects stem from the inhibition of DNA synthesis and the induction of apoptosis, among other mechanisms [1].

1,6,2',6'-O-Tetraacetyl-3-O-trans-p-coumaroylsucrose is a natural product for research related to life sciences. The catalog number is TN5847 and the CAS number is 138195-49-0.

3-O-cis-p-Coumaroyltormentic acid is a useful organic compound for research related to life sciences and the catalog number is T126213.

Ammonium, (3-(p-ethyldimethylammoniophenyl)propyl)ethyldimethyl-, diiodide is a bioactive chemical.

P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).

5'-O-DMTr-2'-O-MOE inosine 3'-P-methyl phosphonamidite is a Nucleoside Phosphoramidite.

Aniline, p-(3-phenylpropoxy)- is a bioactive chemical.