UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.

UNC4976 TFA, a positive allosteric modulator (PAM) peptidomimetic of the CBX7 chromodomain, promotes binding to nucleic acids. It concurrently inhibits the H3K27me3-specific recruitment of CBX7 to target genes and enhances non-specific interaction with DNA and RNA [1].

MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain. It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 μM. MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.

UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).