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By Target- HSP
- MAPK(1)
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Results for "
cc-99677
" in TargetMol Product Catalog- Inhibitors & Agonists1
CC-99677
CC99677,Gamcemetinib,CC 99677
T393211887069-10-4
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM).
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