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By Target- Apoptosis
- NAMPT(1)
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Results for "
chs828
" in TargetMol Product Catalog- Inhibitors & Agonists3
CHS-828
CHS 828,GMX1778
T1998200484-11-3
CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).
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CHS-828 nicotinate
T713611160589-73-0
CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, doxorubicin in 47%, etoposide in 38% and Ara-C in 14% of AML samples.
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ArgTX-93 TFA
T713591161025-20-2
ArgTX-93 is a highly potent and subfamily selective antagonist of the NMDARs and AMPARs.
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