combretastatin a1 phosphate tetrasodium

Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor targeting the colchicine-binding site. By inducing tubulin depolymerization, it inhibits the Wnt β-catenin pathway and deactivates AKT, possessing both anti-tumor and anti-vascular properties.

1-Naphthyl phosphate potassium salt inhibits non-specific phosphatase.

Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) and sphingosine-1-phosphate (d18:1) that has a 17-carbon base. Sphinganine-1-phosphate (d17:0) levels are lower in surgical and cadaver trabecular meshwork samples isolated from patients with primary open angle glaucoma compared with control samples.

A1/A3 AR antagonist 1 (Compound 10) is a potent, dual adenosine 1 (A1) and adenosine 3 (A3) receptor antagonist that acts on human A1 (Ki: 37.6 nM), human A3 (Ki: 25.4 nM) and rat A1 (Ki: 1.47 nM). 1 Can be used to study renal failure, inflammatory lung disease and Alzheimer's disease.

A2A A1 AR antagonist-1 (compound 1a) is a potent dual antagonist with Ki values of 5.58 nM and 24.2 nM for A2A and A1 AR, respectively, demonstrating potential for ischemic stroke research [1].

1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA), an endogenous metabolite, is used in research on non-alcoholic fatty liver disease [1].

α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-D-tyvelose biosynthesis inS. typhi.3Bacterial sucrose phosphorylase converts sucrose and phosphate into D-fructose and α-D-glucose-1-phosphate.4 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen breakdown requires the interplay of several enzymesBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen is synthesized and degraded by different pathwaysBiochemistry(2002) 3.Koropatkin, N.M., and Holden, H.M.Molecular structure of ɑ-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhiJ. Biol. Chem.279(42)44023-44029(2004) 4.Goedl, C., Schwarz, A., Minani, A., et al.Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: Characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of ɑ-Ｄ-glucose 1-phosphateJ. Biotechnol.129(1)77-86(2007)

N-Acetyl-α-D-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, plays a crucial role as an intermediate in the biosynthesis of N-linked glycoproteins. Additionally, it serves as a metabolic precursor for the synthesis of bacterial cell-wall components, particularly teichoic acid and murein [1].

Glucocorticoid Receptor Agonist-1 Phosphate Gly-Glu (TFA) serves as a cleavable linker for the synthesis of Antibody-Drug Conjugates (ADCs).

C18 Ceramide-1-phosphate (d18:1 18:0) is a long-chain molecule identified in murine skin, promoting the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (HUVECs) at concentrations of 0.5 to 5 µM. It exhibits elevated levels in CFPAC-1 pancreatic ductal adenocarcinoma cells compared to pancreatic cancer stem cells, and its myocardial concentration is heightened in Langendorff isolated perfused mouse hearts under an ex vivo ischemia model.

WT-1 A1 is an attractive target for immunotherapy in patients with pancreatic adenocarcinoma.

Combretastatin A1 phosphate, a potent vascular disruptive agent, exhibits anti-angiogenic effects on tumors and holds potential for research on pancreatic neuroendocrine tumors.

Glucocorticoid Receptor Agonist-1 Phosphate Ala-Ala-Mal functions as a glucocorticoid receptor agonist, utilized in the formulation of anti-CD40 antibody agent conjugates (ADC). It serves as a research tool for exploring inflammation and immune regulation [1].

Galactose 1-phosphate Potassium salt (α-D-Galactose-1-phosphate Dipotassium Pentahydrate) is an intermediate in the galactose metabolism and nucleotide sugars metabolism pathways.

α-D-Glucose 1-phosphate disodium salt is converted into D-glucose-6-phosphate by the enzyme phosphoglucomutase.

D-Fructose 1-phosphate disodium salt, a derivative of fructose, serves as a crucial intermediate in glucose metabolism.

Glucocorticoid Receptor Agonist-1 Phosphate (Gly-Glu-Br) is an antibody-drug conjugate (ADC) linker utilized in the synthesis of ABBV-154, ABBV-927, ABBV-368, and related analogs [1].

Sphinganine 1-phosphate, also known as D-erythro-Dihydrosphingosine 1-phosphate, is a polar sphingolipid metabolite. It plays a crucial role in regulating various cellular processes including cell migration, differentiation, survival, and complex physiological processes.

Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated inactivation of AKT to inhibit the Wnt/β-catenin pathway, and can be used to study hepatocellular carcinoma.

α-D-Glucose-1-phosphate disodium hydrate is used in various medical and biochemical applications, including as a precursor in the synthesis of glucuronic acid, a cytostatic compound vital for cardiopathic therapy, an antibiotic, an immunosuppressive agent, and a component in circulatory system therapy [1].

Glucocorticoid Receptor Agonist-1 Phosphate Ala-Ala-Br is a drug-linker conjugate for antibody-drug conjugates (ADCs), serving as a reaction reagent in the creation of anti-CD40 antibody agent conjugates [1].

Galactose 1-phosphate, an intermediate substance in both galactose metabolism and nucleotide sugar processes, plays a crucial role in the biochemical pathways involved.

C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.

Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, and GPR12. As an intracellular second messenger, it mobilizes Ca2+ and acts as an extracellular ligand for G-protein coupled receptors. This important lipid mediator is generated from sphingosine (HY-113498) or other membrane phospholipids.

Mannose 1-phosphate, an endogenous metabolite, serves as a substrate for the enzyme GDP-mannose pyrophosphorylase to synthesize GDP-Man [1].