compound 19, pik-iii analogue

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)

Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.

19-Hydroxy-10-deacetylbaccatin III (compound 13), a taxane with potential antitumor activity, exhibits low cytotoxicity towards A498 and NCI-H226 cell lines, inhibiting their growth by 16.6% and 32% respectively at a concentration of 30 μg mL [1].

CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastri

19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol are new antitumor taxanes from Taxus wallichiana.