cy5 peg5 azide

Cy5-PEG5-azide is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.

Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.

5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.

Thalidomide-5-methyl is a Thalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein.

Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase and a ligand for E3 ligase, offering potential for studying various diseases.

Azido-PEG5-azide, a PEG-based PROTAC linker, is used in PROTAC synthesis.

Thalidomide-5-propargyne-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, is utilized in recruiting CRBN protein and can be linked to a protein ligand via a linker to form PROTACs [for protein degradation].

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based linker compound employed in PROTAC synthesis [1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].

Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) linker compound, designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].

PROTAC EGFR Degrader 5 (Compound 10), a potent degrader of EGFR Del19 in HCC827 cells, achieves this with a DC50 of 34.8 nM. This compound effectively induces apoptosis in HCC827 cells and causes cell cycle arrest in the G1 phase [1].

Pomalidomide-5-C10-NH2 hydrochloride, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand via a linker to construct a PROTAC [1].

Pomalidomide-5-C11-NH2 hydrochloride is a Pomalidomide-derived cereblon (CRBN) ligand that facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to create a PROTAC [1].

Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide-based cereblon ligand designed for CRBN protein recruitment. It facilitates the formation of PROTAC molecules by linking to target protein ligands, such as THAL-SNS-032, via a connector.

Pomalidomide-5-C8-NH2 hydrochloride, a Pomalidomide-based cereblon (CRBN) ligand, is instrumental in the recruitment of CRBN protein. This compound can be linked to the protein ligand via a linker to form PROTAC [1].

PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].

PROTAC BRD9 Degrader-5 is a proteolysis targeting chimera (PROTAC) designed to specifically degrade Bromodomain-containing protein 9 (BRD9).

Azide-PEG-azide (MW 20000) is a polyethylene glycol (PEG)-based linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Thalidomide-5-CH2-NH2 (hydrochloride) is a Thalidomide derivative that acts as a cereblon ligand for CRBN protein recruitment. This compound can be linked to a protein ligand via a linker to form PROTACs.

Lenalidomide 5'-piperazine, a cerebellar ligand utilized in PROTAC development, facilitates the binding of an E3 ligand to its terminal piperazine. This connection enables subsequent chemical reactions aimed at generating a protein deactivator, employing a rigid linker [1].

E3 Ligase Ligand-linker Conjugate 5, a combination of an E3 ligase ligand and linker, comprises Thalidomide and its specific Linker. This conjugate acts as a Cereblon ligand to attract the CRBN protein and functions as a crucial intermediate in the production of full PROTAC molecules.

Pomalidomide-5-C5-NH2 hydrochloride is a Pomalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein and can be linked to a protein ligand via a linker to form PROTAC [1].

PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].

5-Aminothalidomide-cyclohexane is a conjugate of an E3 ubiquitin ligase ligand-linker.

SMARCA2 ligand-5 is a PROTAC (proteolysis targeting chimera) target protein ligand.

Thalidomide-5-piperazine-C-piperidine-CO-C8-NH2 is a coupled compound acting as an E3 ubiquitin ligase ligand-linker conjugate.

CDLI-5 is a cereblon degrader-linker conjugate used for synthesizing cereblon degrader antibody conjugates (cDAC).

PROTAC IRAK4 degrader-5 is a Cereblon-based compound designed to selectively degrade IRAK4.

Thalidomide-5-propoxyethanamine acts as a cereblon (CRBN) ligand derived from Thalidomide, and it serves the purpose of recruiting the CRBN protein.

Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.

cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1].

Cy5-PEG5-amine (hydrochloride) is a PEG-derived PROTAC linker used in PROTAC synthesis[1].

N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a polyethylene glycol (PEG) derivative functioning as a PROTAC linker, essential for synthesizing proteolysis targeting chimeras (PROTACs)[1].

m-PEG-azide (MW 10000), a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

m-PEG-azide (MW 2000) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating the selective degradation of target proteins through the ubiquitin-proteasome system within cells.

Thalidomide-5-O-C14-NH2 hydrochloride, a cereblon ligand based on Thalidomide, facilitates the recruitment of CRBN protein. By incorporating a linker, this compound can be conjugated to a ligand to create PROTACs [1].

N-(m-PEG4)-N'-(azide-PEG3)-Cy5 is a polyethylene glycol (PEG)-based linker used in the synthesis of protein degraders, known as PROTACs [1].

'NN'-bis-(azide-PEG3)-Cy5 is a polyethylene glycol (PEG)-derived linker used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Thalidomide-5-O-C4-NH2 hydrochloride, a cereblon ligand derived from Thalidomide, facilitates the recruitment of CRBN protein. It can be tethered to a ligand for protein recruitment through a linker, enabling the formation of PROTACs [1].

Thalidomide-5-O-C2-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1].

Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].

m-PEG-azide (MW 5000) is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands to enable selective protein degradation via the ubiquitin-proteasome system in cells.

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride serves as a specialized cerebellar ligand suitable for PROTAC development. It integrates an E3 ligand with a terminal piperidine, facilitating subsequent chemical reactions. This compound enables the creation of a protein degradant featuring a rigid connector [1].

Fmoc-5-aminopentanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.