cy5 peg6 acid

Cy5-PEG6-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516

Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Cl-PEG6-acid is a PEG-based linker for PROTACs that connects two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-5-aminopentanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Bis-PEG6-acid is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Cy5-PEG6-NHS ester (chloride) is a PEG-based PROTAC linker utilized for PROTACs[1] synthesis.

Acid-PEG6-C2-Boc is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based PROTAC linker used in the synthesis of PROTACs[1].

N-(m-PEG4)-N'-(PEG2-acid)-Cy5 is a polyethylene glycol (PEG)-derived linker compound utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs) [1].

6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].

Boc-6-aminohexanoic acid, an alkyl ether-based linker, is utilized in PROTAC synthesis.

Hydroxy-PEG6-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

5-Maleimidovaleric acid, a cleavable linker for antibody-drug conjugates (ADCs) synthesis, is employed as an ADC linker[1].

N-(m-PEG9)-N'-(PEG5-acid)-Cy5 is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

Thiol-PEG6-acid is a PEG-based linker for PROTACs, joining two essential ligands vital for PROTAC molecule formation. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG6-acid is a PEG-based linker for PROTACs, essential for joining two ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

TCO-PEG6-acid is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Bis-(PEG6-acid)-SS, a cleavable linker composed of a six-unit PEG (polyethylene glycol) moiety, is specifically employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Fluorescein-thiourea-PEG6-acid is a polyethylene glycol (PEG) derived linker frequently used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker suitable for synthesizing PROTACs [1].

N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a polyethylene glycol (PEG)-derived PROTAC linker used in PROTAC synthesis [1].

6-Maleimidocaproic acid sulfo-NHS serves as an alkyl/ether-based PROTAC linker, facilitating the synthesis of PROTACs.

Cy5-PEG4-acid (chloride) serves as a PEG-based PROTAC linker, suitable for synthesizing PROTACs[1].

Azido-PEG6-acid is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras] that connects two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Acid-PEG6-mono-methyl ester is a polyethylene glycol (PEG)-based PROTAC linker suitable for the synthesis of PROTACs [1].

N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

DNP-PEG6-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, thereby enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(m-PEG4)-N'-(PEG4-acid)-Cy5 is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs[1].

Thalidomide-5-PEG6-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, facilitates the recruitment of the CRBN protein and can be tethered to a ligand for protein conjugation via a linker to construct PROTACs [1].

Br-PEG6-C2-acid, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Ald-Ph-PEG6-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5 is a polyethylene glycol-based linker (PEG-PROTAC) suitable for PROTAC development through chemical synthesis [1].

m-PEG4-(CH2)6-Phosphonic acid is a polyethylene glycol-based linker compound designed for synthesizing proteolysis targeting chimeras (PROTACs)[1].

Cbz-NH-PEG6-C2-acid [CB92080147] is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG6-acid, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG6-(CH2)6-Phosphonic acid functions as a PEG-based PROTAC linker for PROTAC synthesis [1].

Mal-amido-PEG6-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-methyl-N'-methyl-O-(m-PEG4)-O'-(acid-PEG5)-Cy5, a PEG-based PROTAC linker utilized in the synthesis of PROTACs, serves as an efficient chemical compound for protein degradation [1].

5-endo-BCN-pentanoic acid, an alkyl chain-based PROTAC linker, facilitates the synthesis of PROTACs[1].