cyclo(pro-val)

Cyclo(Pro-Val) (Cyclo(prolylvalyl)) is obtained from the marine fungus and shows moderate antifungal and weak antitumor activities. Cyclo(Pro-Val) inhibits the growth of Bacillus subtilis with MIC of 0.8 g/L.

Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microorganisms (e.g., R. fascians LMG 3605) and inhibits Gram-positive plant pathogens.Cyclo(L-Pro-L-Val) significantly inhibited IKKα phosphorylation and IκBα and NF-κB activation as well as iNOS and COX-2 activation in a concentration Cyclo(L-Pro-L-Val) significantly inhibited the phosphorylation of IKKα, IKKβ, IκBα, and NF-κB, as well as the activation of iNOS and COX-2 in a concentration-dependent manner, and is a potential therapeutic agent for the treatment of inflammation-related diseases.

Boc-Val-Pro-Arg-MCA TFA is a sensitive fluorescent substrate that is a thrombin substrate for the determination of trypsin-like serine protease activity.

Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.

Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) acts as a CatG enzyme inhibitor, exhibiting IC50 values ranging from 111 to 225 mM.

Myristoyl tetrapeptide Ala-Ala-Pro-Val is a bioactive peptide that stimulates the expression of extracellular matrix (ECM) proteins and inhibits the expression of metalloproteinases (MMPs).

Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor with antitumor properties, utilized in the research of acute myeloid leukemia [1].

Cyclo(Phe-Pro) acetate(14705-60-3 free base), known as a secondary metabolite of some bacteria and fungi, is also produced by Vibrio vulnificus.

Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is a 13-mer synthetic peptide with a sequence homologous to seven amino acids of the SV40 T antigen, known for its capability to induce nuclear transport [1].

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide and a synthetic α5β1 integrin ligand. It competitively inhibits the binding of invasin (Inv) to α5β1 integrin on Caco-2 cells [1].

Maculosin is a secondary metabolite of fungi and bacteria.

c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm a highly efficient, selective and short-acting peptide V2 receptor agonist (V2R), with EC50s of hV2R and rV2R being 0.25 and 0.05 nM, respectively.

Fmoc-Val-Ser(psi(Me,Me)pro)-OH is a dipeptide.

H-Val-Pro-Pro-OH(TFA), a proline peptide derivative from milk, is an ACE inhibitor with IC50 of 9 M.

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a peptide substrate specific to HIV-1 protease, serving as the variable component in peptidolytic assays designed to measure the enzyme's inhibition [1] [2].

Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density. It induces neurite outgrowth and branching of chick cortical neurons in vitro when used at concentrations of 16 and 32 μM. It increases phosphorylation of the PI3K substrate Akt, and neurite outgrowth induced by cyclo(L-Phe-L-Val) can be blocked by the PI3K inhibitor LY294002 . Cyclo(L-Phe-L-Val) enhances axon sprouting of calcitonin gene-related protein positive (CGRP+) primary afferents in the spinal cord following crush injury and of serotonin neurons in uninjured spinal cord. Cyclo(L-Phe-L-Val) is also a bitter taste component of cocoa and roasted coffee.

Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.

Fmoc-Val-Thr(psi(Me,Me)pro)-OH is a dipeptide.

Cyclo(Pro-Leu) (Cyclo-L-prolyl-L-leucine) is a marine-derived natural product with brine shrimp lethality.

Cyclo(Phe-Pro) (A-64863) known as a secondary metabolite of some bacteria and fungi, is also produced by Vibrio vulnificus.

Cyclo(L-Leu-L-Pro) is a compound from Pseudomonas sesquiterpenes BC42 that exhibits antifungal activity, inhibits fungal pathogens, and inhibits the proliferation of Aspergillus flavus.Cyclo(L-Leu-L-Pro) inhibits conidial germination and conidial formation, and can be used for agricultural biocontrol.

H-Val-Pro-Pro-OH (TFA) is an inhibitor of angiotensin I converting enzyme (ACE) (IC50: 9 μM).H-Val-Pro-Pro-OH (TFA) is a milk-derived proline peptide derivative.

Ala-Ala-Pro-Val-chloromethylketone serves as an irreversible inhibitor of human neutrophil elastase (NE), utilized in researching chronic inflammatory airway diseases.

Val-Arg-Pro-DL-Arg-Fluoromethylketone, a potent MALT1 inhibitor, exhibits anticancer activity by inhibiting cell proliferation and migration [1].

H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM).