cytidine5'triphosphate

Cytidine 5'-diphosphate disodium (CDP sodium salt) produces CTP to support DNA and RNA biosynthesis and ribonucleotide reductase to produce dCMP.

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate is an intermediate in the synthesis of capecitabine.

Cytidine 5'-triphosphate (5'-CTP), also known as cytidine triphosphate, is a nucleoside triphosphate that plays a crucial role as a building block for nucleotides and nucleic acids, as well as lipid biosynthesis. It is synthesized through the catalytic action of cytidine triphosphate synthase, which converts uridine 5'-triphosphate (UTP) to cytidine 5'-triphosphate. Cytidine 5'-triphosphate is an essential biomolecule in T. gondii's de novo pyrimidine biosynthetic pathway.

BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase. It exhibits outstanding selectivity for varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) owing to its phosphorylation by the virus-specific thymidine kinase.

5-Azacitidine, a purine nucleoside analog, exhibits wide-ranging antitumor efficacy against indolent lymphoid malignancies by inhibiting DNA synthesis and inducing apoptosis, among other mechanisms [1].

Uridine 5′-triphosphate tris salt (Uridine 5'-triphosphoric acid) is an agonist to the P2Y receptor and has been used to study concentrations of intracellular Ca2+, as well as a phosphate donor for in vitro kinase assays.

Deoxythymidine-5'-triphosphate (dTTP) is a nucleoside triphosphate involved in DNA synthesis.

5-Azacytidine 5′-triphosphate (5-aza-CMP), a cytidine analog, selectively inhibits the incorporation of [^3H]CTP into RNA during the DNA-dependent RNA polymerase reaction, while not affecting the incorporation of [^3H]UTP [1].

3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that suppresses DNA-dependent RNA polymerases I and II activity. It competitively obstructs the inclusion of UTP into RNA, demonstrating strong inhibition with a dissociation constant (Ki) of 2.0 μM[1].

N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].

N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog employed in the process of in vitro RNA transcription.

2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) is a naturally occurring small molecule nucleotide used in cells for DNA synthesis or replication. 2'-Deoxyadenosine-5'-triphosphate (dATP) is a substrate for DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate (dATP) is an inhibitor of RNA through an inactive alpha4beta4 quaternary structure. Deoxyadenosine-5'-triphosphate inhibits RNA through the inactive α4beta4 quaternary structure.2'-Deoxyadenosine-5'-triphosphate has been associated with cardiomyocyte growth.

N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a modified nucleotide that enhances mRNA synthesis by minimizing immunogenicity and enhancing stability.

5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while reducing innate immune responses in human and mammalian cells when used to replace unmodified mRNA [1].

5'-GTP trisodium salt hydrate, an activator of the signal-transducing G proteins, serves as a precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.

2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide that serves as a substrate for DNA polymerase, which is used in cells for DNA synthesis or replication.

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].

5-Azacytidine 5'-triphosphate sodium, a cytidine analog, selectively inhibits the incorporation of [3 H]CTP into RNA by DNA-dependent RNA polymerase, without affecting the incorporation of [3 H]UTP [1].

Guanosine 5'-triphosphate-5'-adenosine, known as a 5′ cap analog, serves as a fluorescent substrate analog.

Cytidine 5'-triphosphate disodium salt is one of the endogenous metabolites and is a cation-permeable ligand-gated ion channel agonist.

5’-O-DMTr-3’-O-phthalimidopropyl cytidine is a useful organic compound for research related to life sciences and the catalog number is TNU1661.

6-Chloropurine riboside-5'-triphosphate serves as both an inhibitor and an activator in biochemical processes. It inhibits the RNA triphosphatase mRNA-capping enzyme subunit β (Cet1; IC50 = 2 µM for the GTPase activity of the S. cerevisiae enzyme), proving its efficacy against the enzyme responsible for the capping of mRNA molecules. Additionally, it acts as a phosphorylated derivative of 6-chloropurine riboside. This compound also activates the E. coli enzyme aspartate carbamoyltransferase (EC50 = 0.76 mM), demonstrating its versatility in modulating enzyme activities. It is instrumental in the synthesis of cytokinins with anticancer properties and a photoclickable form of ATP, highlighting its applications in biochemical synthesis and potential therapeutic uses.

3'-O-Methylguanosine-5'-O-triphosphate (3'-O-methyl GTP), a methylated derivative of GTP, serves as a chain termination reagent in synthesizing early RNA polymerase II elongation intermediates.

5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate immune responses in human and other mammalian cells when substituting unmodified mRNA [1].

2’-Fluoro-2’-deoxy-arabinoadenosine 5’-triphosphate (triethylamine) is a purine nucleoside analog with significant antitumor properties, particularly effective against indolent lymphoid malignancies. Its anticancer efficacy is primarily achieved through the inhibition of DNA synthesis and the induction of apoptosis among other mechanisms [1].

Cytidine 5′-diphosphoethanolamine, a key intermediate in phosphatidylethanolamine synthesis, also serves as a stimulant of Ach synthesis [1].

Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a useful organic compound for research related to life sciences and the catalog number is T67406.

Rev 2’-O-MOE-C(Bz)-5’-amidite; N4-Benzoyl-3'-O-(4,4’-dimethoxy trityl)-2'-O-(2-methoxyethyl)cytidine-5’-CED phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1531.

4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4. It is utilized in crosslinking experiments and labeling of transcriptional complexes [1] [2].

3'-Amino-3'-deoxyguanosine-5'-O-triphosphate (3'-amino-dGTP), an amine-modified nucleotide, effectively terminates RNA strand synthesis as catalyzed by RNA polymerase in E. coli. This compound has also been utilized in creating a non-hydrolyzable derivative of the alarmone guanosine pentaphosphate (pppGpp).

2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate is a fluorinated analog of ATP, the pivotal energy substrate for cellular metabolism, and acts as an inhibitor of E. coli RNA polymerase (Ki = 200 µM).

N4-Benzoyl-5’-O-DMTr-2’-O-(N3-trifluoroacetyl) aminopropyl cytidine 3’-CED phosphoramidite is a useful organic compound for research related to life sciences. The catalog number is TNU1663 and the CAS number is 165381-54-4.

2'-O-Methyl-5-methyluridine 5'-triphosphate triethylammonium salt is a Nucleoside Triphosphate.

4'-Azidothymidine 5'-triphosphate exerts selectively action on both reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta.

Uridine 5'-triphosphate tris salt is an endogenous metabolite .

3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine, a cytidine analog, inhibits DNA methyltransferases (e.g., Zebularine), exhibiting potential anti-metabolic and anti-tumor activities [1].

2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate (ammonium), a purine nucleoside analog, exhibits extensive antitumor properties, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

3'-Azido-3'-deoxy-5-methyl-beta-L-cytidine is a Nucleoside Derivative - L-nucleoside, Azido-nucleoside.

5-Modified pyrimidine nucleoside; building block for nucleic acid

5-(Trifluoromethyl)cytidine is a Nucleoside Derivative - Fluoro-Modified nucleoside, 5-Modified pyrimidine nucleoside.

Isoguanosine-5'-O-triphosphate, an isomer of guanosine 5'-triphosphate (GTP) and a phosphorylated derivative of crotonoside, does not promote microtubule assembly like GTP. At a concentration of 2 mM, it hampers transcription and triggers T to C mutations in reverse transcriptase assays. This compound aids in assessing the substrate specificity of both phosphofructokinase and mutT homolog 1 (MTH1).

Cytidine 5'-diphosphate trisodium salt (CDP) can produce Cytidine triphosphate for synthesis of DNA and RNA through the transfer of phosphoryl group from ATP to cytidine monophosphate (CMP) catalyzed by uridine monophosphate kinase (UMPK).

2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium, an ATP analog, exhibits robust mixed-type inhibition of poly(AU) synthesis.

2’-O-Methyl-5-methyluridine 5’-triphosphate (triethylammonium), a thymidine analog, exhibits insertional activity in replicated DNA. This characteristic enables its application in labeling cells and monitoring DNA synthesis [1].

7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium, a guanosine 5'-phosphate derivative, serves as a potent inhibitor of cap-dependent translation, with its sodium phosphorothioate analog enhancing its efficacy [1].

3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine is a Nucleoside Derivative - L-nucleoside, Azido-nucleoside, Fluoro-modified nucleoside, 5-Modified pyrimidine nucleoside.

N4-Bz-5'-O-DMTr-3'-deoxy-3'-fluoro-beta-D-xylofuranosyl cytidine-2'-CED-phosphoramidite is a useful organic compound for research related to life sciences. The catalog number is TNU1666 and the CAS number is 1555759-30-2.

Diguanosine 5′-triphosphate (Gp3G) is a kind of homodinucleotide from by GTP:GTP guanylyltransferase. Diguanosine 5′-triphosphate is a virus-specific oligonucleotide, can be used to prime reovirus transcription and inhibit RNA methylation.

5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine is a Nucleoside Derivative - 5'-Modified nucleoside; 5-Modified pyrimidine nucleoside, Fluoro-modified nucleoside; Drugs and Inhibitors; 5'-Deoxy nucleoside; Capecitabine impurity E.