cytochalasin a

Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy

Cytochalasin O (compound 13), a secondary metabolite produced by the phytopathogenic fungus P. sp. CIB-109 [1], is characterized by its bioactive properties.

Cytochalasin K (Compound 7) is a cytochalasin known to inhibit wheat root elongation, exhibiting an IC50 value of 22.58 μM [1].

Cytochalasin N, derived from the endophytic fungus Phomopsis sp.CIB-109 [1], is a cytorelaxin.

Cytochalasin R (compound 17), an analogue of cytochalasin, is derived from the endophytic fungus Phomopsis sp. xz-18 and exhibits potential antifungal activity [1].

Cytochalasin C is a cell-permeable fungal toxin that can induce the formation of nuclear sticks. Cytochalasin C is 10 times less toxic than cytochalasin D in mice.

Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong

Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) is a potent inhibitor of actin incorporation into filaments.

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit

Evofolin B is a natural compound isolated from the stem bark of Zanthoxylum ailanthoides. Evofolin B has an inhibitory effect on the superoxide anion produced by human neutrophils in response to formyl-L-methionine-L-leucine-L-phenylalanine/cytochalasin B (fMLP/CB).

2'-Hydroxygenistein has antifungal activity, dimerization of it causes a remarkable increase of antifungal activity. It shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B. 2'-Hydroxygenistein of genistein can enhance its antioxidant activity and cell cytotoxicity in MCF-7 human breast cancer cells.

2'-Hydroxydaidzein is an isoflavonoid phytonutrient found in plant species, when a natural compound. 2'-Hydroxydaidzein has antioxidant activity, driven mainly by o-hydrogen bond dissociation enthalpy (BDE) and hydrogen atom transfer (HAT) mechanisms. 2'-Hydroxydaidzein inhibits chemical mediators in inflammatory cells and may be of value in the treatment and prevention of inflammatory diseases associated with excessive chemical mediator production. It may have a role in the treatment and prevention of central and peripheral inflammatory diseases associated with excessive chemical mediator production. 2'-Hydroxydaidzein inhibited the release of neutrophils and formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB) in rats, with IC(50) values of 2.8+/-0.1 and 5.9+/-1.4 microM, respectively.