d ( ) citramalic acid (lithium salt)

D-(-)-Citramalic acid (lithium salt) is a biochemical intermediate involved in the anaerobic metabolism of glutamate through the methylaspartate pathway of C. tetanomorphum. It also plays various roles in other aspects of bacterial metabolism.

L-aspartic acid potasium salt（VX-548） is an amino acid widely found in plants and animals.L-aspartic acid potasium salt drives the production of nitrogen oxides, which promotes phagocytosis and contributes to fish survival.L-aspartic acid potasium salt may stimulate antibiotics. The stimulatory effect may be related to precursors involved in aspartic acid-4-semialdehyde biosynthesis.

Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, Valproic acid sodium salt increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproic acid sodium salt may also affect potassium channels, thereby creating a direct membrane-stabilizing effect.

5'-Guanylic acid disodium salt (GMP-5) belongs to the class of organic compounds known as purine ribonucleoside monophosphates. In particular, L-Glutamic acid and guanosine monophosphate can be biosynthesized from xanthylic acid and L-glutamine; which is catalyzed by the enzyme GMP synthase [glutamine-hydrolyzing]. In addition, Guanosine triphosphate and guanosine monophosphate can be biosynthesized from diguanosine tetraphosphate; which is catalyzed by the enzyme bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. In humans, guanosine monophosphate is involved in the kanamycin action pathway, the telithromycin action pathway, the tobramycin action pathway, and the erythromycin action pathway. Guanosine monophosphate is also involved in several metabolic disorders, some of which include the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria (D and L form) pathway. Outside of the human body, guanosine monophosphate can be found in a number of food items such as onion-family vegetables, millet, chinese water chestnut, and red rice. This makes guanosine monophosphate a potential biomarker for the consumption of these food products.

Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

D-(-)-Tartaric acid (D-Tartaric acid; (S, S)-tartarate; D-threaric acid) is mainly located in the cytoplasm. D-(-)-Tartaric acid can be converted into (2S,3S)-cis-fertaric acid and (2S,3S)-trans-fertaric acid. Outside the human body, it can be found in vinegar. This makes it a potential biomarker for the consumption of this food.

L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.

Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate inhibits the enzymatic superoxide source xanthine oxidase with an IC50 of 6 mM and has antioxidative, neuroprotective, and anti-inflammatory effects.

Dodecanedioic acid diammonium salt (1,10-Decanedicarboxylic acid diammonium salt) is a dicarboxylic acid which is water-soluble and involves in a metabolic pathway intermediate to those of lipids and carbohydrates.

D-Pantothenic acid (vitamin B5) is a water-soluble vitamin ubiquitously found in plants and animal tissues with an antioxidant property. D-Pantothenic acid is a component of coenzyme A (CoA) and a part of the vitamin B2 complex. D-Pantothenic acid is a growth factor and is essential for various metabolic functions, including the metabolism of carbohydrates, proteins, and fatty acids. This vitamin is also involved in the synthesis of cholesterol, lipids, neurotransmitters, steroid hormones, and hemoglobin.

Isethionic acid sodium salt (Sodium isethionate) is an organosulfur compound containing a short chain alkane sulfonate linked to a hydroxyl group. Mammals are able to endogenously synthesize Isethionic acid sodium salt via taurine through a possible enzymatic deamination process. Isethionic acid sodium salt can be found in both human plasma and urine. Higher plasma levels of Isethionic acid sodium salt have been shown to be protective against type 2 diabetes.

Phytic acid sodium salt (Sodium phytate hydrate) is known to function as a [PO4]3- storage depot and a precursor for other inositol phosphates and pyrophosphates. It is a potent chelator of divalent and trivalent cations in vitro.

D-(-)-Quinic acid (Kinic acid) is a cellular metal ion chelator, capable of promoting reactions with metal M(II,III) ions under pH-specific conditions. It may possess potent inhibition against alpha-mannosidase and alpha-fucosidase.

Pseudolaric acid A-O-β-D-glucopyranoside (Pseudolaric acid A-O-beta-D-glucopyranoside) is a natural product with antibacterial, anticancer

Ursulcholic acid trisodium salt (Ursodeoxycholic acid disulfate trisodium salt) is a soluble form of ursodeoxycholic acid which has antihyperlipidemia and gallbladder activity.

Maleic acid disodium salt is a pharmaceutical intermediate used in the synthesis of other active compounds.

D-Glucuronic acid sodium salt monohydrate (Sodium D-glucuronate) is a carboxylic acid and highly soluble in water. In humans, glucuronic acid is often linked to toxic or poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport.

EST64454 Maleic acid salt is the maleic acid salt form of EST64454.EST64454 is a highly soluble σ1 receptor antagonist clinical candidate for the treatment of pain.

Sultosilic acid piperazine salt (A-585) is a novel lipid-lowering compound that can be used to study type IIb familial combined hyperlipidemia.

α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcytosine hydroxylase, and has an inhibitory effect on ATP synthase and mTOR signaling.

Glycyrrhizinic acid, potassium salt can reduce ventricular arrhythmias caused by veratrol

In cells, D-Glucose 6-phosphate potassium salt (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the beginning of both glycolysis and the pentose phosphate pathways. It also can be stored as glycogen when blood glucose levels are high.

D-γ-Glutamyl-D-glutamic acid acetate is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain.

Diethyldithiocarbamic acid copper salt is a chelating agent used in various metal, protein, and enzyme experiments. It can also serve as a complexing agent for synthesizing various organic compounds, including heterocyclic compounds, and as an inducer for copper-mediated cell death.

D-Glucuronic acid is an important intermediate isolated from many gums. It has anti-inflammatory effects on the skin. It and its derivative glucuronolactone act as preventive liver detoxifiers for human health.

D-(-)-Lactic acid sodium (Sodium D-lactate) is an organic acid. It is a chiral molecule, consisting of two optical isomers, L-lactic acid and D-lactic acid, with the L-isomer being the most common in living organisms. D-(-)-Lactic acid sodium also is a microbial metabolite.

Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous animals, is used as a detergent to solubilize fats for absorption. It is used as a cholagogue and cholerectic.

1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 microM.

Fusidic acid sodium salt (SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.

UDP-Glucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1 1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998)

Trans-Caffeoyl-6-O-D-gluconic acid, a natural product, is isolated from the almost mature fruits of Evodia rutaecarpa (Juss.) Benth. [1].

α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-D-tyvelose biosynthesis inS. typhi.3Bacterial sucrose phosphorylase converts sucrose and phosphate into D-fructose and α-D-glucose-1-phosphate.4 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen breakdown requires the interplay of several enzymesBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen is synthesized and degraded by different pathwaysBiochemistry(2002) 3.Koropatkin, N.M., and Holden, H.M.Molecular structure of ɑ-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhiJ. Biol. Chem.279(42)44023-44029(2004) 4.Goedl, C., Schwarz, A., Minani, A., et al.Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: Characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of ɑ-Ｄ-glucose 1-phosphateJ. Biotechnol.129(1)77-86(2007)

1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.

D-Trimannuronic acid is an alginate oligomer that originates from seaweed. It can induce TNF-α secretion by mouse macrophage cell lines, making it valuable in pain and vascular dementia research [1][2][3].

5-Phospho-D-ribose 1-diphosphate (PRPP) is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism. It is also an intermediate in the synthesis of plant hormones, alkaloids, and other secondary metabolites from glucose. Several phosphoribosyltransferases (PRTases) use PRPP as a substrate to add a 5-phosphoribosyl group to another substrate, as in the production of adenosine monophosphate from adenine and PRPP by adenine PRTase. N/A

1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of Pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca2+ and Mg2+.

Quinovic acid 3-O-(3',4'-O-isopropylidene)-beta-D-fucopyranoside is a natural product for research related to life sciences. The catalog number is TN4885 and the CAS number is 182132-59-8.

9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration inob/obmice. It also increases body weight gain and body fat in weanling mice.4[Matreya, LLC. Catalog No. 1278] 1.Shultz, T.D., Chew, B.P., Seaman, W.R., et al.Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cellsCancer Lett.63(2)125-133(1992) 2.Moya-Camarena, S.Y., Heuvel, J.P.V., Blanchard, S.G., et al.Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARαJ. Lipid Res.40(8)1426-1433(1999) 3.Moloney, F., Toomey, S., Noone, E., et al.Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissueDiabetes56(3)574-582(2007) 4.Pariza, M.W., Park, Y., and Cook, M.E.The biologically active isomers of conjugated linoleic acidProg. Lipid Res.40(4)283-298(2001)

Pomolic acid 28-O-beta-D-glucopyranosyl ester is a natural product

Ribavirin 5'-monophosphate (lithium salt) directly inhibits IMP dehydrogenase (converts IMP to XMP).

Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-of-function protects against cholestatic liver injury by attenuating hepatic bile acid accumulation in bile duct ligated miceToxicol. Sci.161(1)34-47(2018)

Taraxinic acid β-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN6269 and the CAS number is 75911-14-7.

UDP-a-D-Galactose disodium salt is a donor substrate for galactosyltransferases employed in the biosynthesis of galactose-containing oligosaccharides[1].

D-Nonamannuronic acid, an alginate oligomer derived from marine brown algae and certain Gram-negative bacteria, serves as an investigative compound in pain and vascular dementia research [1] [2] [3] [4].

4-(β-D-Glucopyranosyloxy)benzoic acid, a phenolic glucoside, can be isolated from fennel seeds [1].

(+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. Biotin is an essential coenzyme for certain carboxylases and is used to modify histones and regulate gene transcription. Biotinidase has key roles in intestinal absorption of biotin, the transport of biotin in plasma, and in the regulation of histone biotinylation. (+)-Biotin 4-amidobenzoic acid is hydrolyzed by biotinidase to release 4-aminobenzoic acid (PABA), which can be quantified by either fluorescent or colorimetric methods. This approach is used in biotinidase activity assays in newborn screening protocols to evaluate biotinidase deficiency.

D-Galacturonic acid monohydrate is a natural product.

L-2-Phosphoglyceric acid disodium salt is a glyceric acid which serves as the substrate in glycolysis. It is catalyzed by enolase into phosphoenolpyruvate.

Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.

Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) is a natural product for research related to life sciences. The catalog number is TN6498 and the CAS number is 1309929-72-3.