d-myo-inositol-1,2-diphosphate

Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,2)P2 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)P3 at initiating Ca2+ release when injected into Xenopus oocytes.

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).

D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) is an epimer of myo-inositol that is found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity.

1,2-O-Isopropylidene-β-D-fructopyranose is a natural product from Uncaria sessilifructus

3-Deoxy-3-fluoro-1,2:5,6-di-O-isopropylidene-a-D-gluco-pentofuranose is a Carbohydrate Derivative.

3-O-Benzyl-1,2:5,6-di-O-isopropylidene-alpha-D-allofuranose is a Carbohydrate.

5-O-TBDPS-1,2-di-O-isopropylidene-3-keto-alpha-D-xylofuranoside is a carbohydrate.

5-O-Benzoyl-1,2-O-isopropylidene-alpha-D-xylofuranose is a Carbohydrate; Used for modified nucleoside.

1,2-Di-O-acetyl-3,5-di-O-benzyl-D-xylofuranose is a valuable organic compound for life sciences research, catalog number TNU1626 and CAS number [146986-45-0].

5-O-benzoyl-1,2-O-isopropylidene-alpha-D-erythro-pent-3-ulofuranose is a Carbohydrate; Used for modified nucleoside.

Ins(1,4,5)P3 is an isomer of the biologically important D-myo-inositol-1,4,5-triphosphate. Unlike its isomer, Ins(1,4,5)P3 does not evoke a rise in intracellular calcium when added to cells. It is not known if Ins(1,4,5)P3 can act as a competitive inhibitor of biologically-active inositol phosphates.

5-Phospho-D-ribose 1-diphosphate (PRPP) is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism. It is also an intermediate in the synthesis of plant hormones, alkaloids, and other secondary metabolites from glucose. Several phosphoribosyltransferases (PRTases) use PRPP as a substrate to add a 5-phosphoribosyl group to another substrate, as in the production of adenosine monophosphate from adenine and PRPP by adenine PRTase. N/A

4-C-(Iodomethyl)-1,2-di-O-(1-methylethylidene)-3,5-bis-O-(phenylmethyl)-a-D-ribofuranose is a Carbohydrate Derivative.

6-O-p-Coumaroyl-1,2-di-O-galloyl-b-D-glucopyranose is a useful organic compound for research related to life sciences and the catalog number is T130064.

D-Fructose-1,6-diphosphate trisodium salt octahydrate is a useful organic compound for research related to life sciences and the catalog number is T65105.

1,2:5,6-Di-O-isopropylidene-alpha-D-ribo-hexofuranose is a pharmaceutical intermediate used in liquid crystal materials.

3-O-Benzyl-1,2:5,6-bis(di-O-isopropylidene)-a-D-allofuranose is a Carbohydrate Derivative.

1,2-Di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose is a carbohydrate derivative.

2-C-Methylene-myo-inositol oxide (NSC 45109), an inositol derivative, promotes pseudohyphal growth in Saccharomyces species [1].

D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,3)P2 can be dephosphorylated to Ins(1)P by inositol polyphosphate 3-phosphatase and further dephosphorylated to inositol by inositol monophosphatase.

D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(4)P1 can be formed by dephosphorylation of Ins(1,4)P2 by inositol polyphosphate 1-phosphatase or dephosphorylated to inositol by inositol monophosphatase.

D-Glucose-1,2-13C2 is the 13C labeled compound of D-Glucose. D-Glucose has a CAS number of 50-99-7. D(+)-Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

1,2-Di-O-acetyl-5-O-benzoyl-3-O-(4-methoxybenzyl)-D-ribofuranose is a useful organic compound for research related to life sciences and the catalog number is TNU1313.

1,2-Di-O-isopropylidene-3-O-(4-methoxybenzyl)-a-D- ribofuranose is a Carbohydrate Derivative.

1,2:4,5-Di-O-isopropylidene-β-D-fructopyranose is a natural from Euphorbia macroclada

Nucleoside Derivatives - 2’-Modified nucleosides; Scaffolds and Templates;Bi-Tricyclic nucleosides

carbohydrate; For modified nucleosides

D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell.

3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions. Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis.

3-O-(4-Methoxybenzyl)-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose is a carbohydrate derivative.

1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-xylofuranose is a carbohydrate derivative.

myo-Inositol-d6 is a deuterated compound of myo-Inositol. myo-Inositol has a CAS number of 87-89-8. Inositol is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation.

1,2-Di-O-isopropylidene-3-O-(2-methoxyethyl)-alpha-D- ribofuranose is a useful organic compound for research related to life sciences and the catalog number is TNU1316.

1,2-Di-O-acetyl-3,5-di-O-benzoyl-3-beta-C-methyl-D-ribofuranose is a carbohydrate derivative.

1,2-Di-O-isopropylidene-5-O-benzoyl-alpha-D-ribofuranoside is a Carbohydrate Derivative.

1,2-O-Isopropylidene-3-O-methyl-D-ribofuranose is a Carbohydrate.

1,2-Di-O-acetyl-5-benzoyl-3-O-methyl-D-ribofuranose is a carbohydrate derivative.

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.

D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) is a second messenger produced in cells by the phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. It binds to Ins(1,4,5)P3 receptors, resulting in the opening of calcium channels and an increase in intracellular calcium.

The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, andmotility. D-myo-Inositol-1,5,6-triphosphate is an intermediate compound, produced by the dephosphorylation of various inositol-tetrakisphosphate forms. The triphosphate can be further metabolized to produce inositol-biphosphate mediators. The biological roles of D-myo-inositol-1,5,6-triphosphate remain to be determined.

The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure. They act as second messengers, regulating a wide array of cellular functions. D-myo-inositol-1,3,4,6-tetraphosphate(Ins(1,3,4,6)-P4) largely acts an intermediate, serving as substrate for inositol-1,3,4,6-tetraphosphate 5-kinase to produce inositol-1,3,4,5,6-pentaphosphate, or inositol-1,3,4,6-tetraphosphate 2-kinase to give inositol-1,2,3,4,6-pentaphosphate. These inositol pentaphosphates can be further phosphorylated to produce inositol-1,2,3,4,5,6-hexakisphosphate, or phytic acid, which serves diverse roles in eukaryotic tissues. Ins(1,3,4,6)-P4 is a poor activator of the inositol 1,4,5-trisphospate receptor in vitro. Other functions of this IP remain to be elucidated.

1,2-Di-O-acetyl-5-O-benzoyl-3-O-(2-methoxyethyl)-D-ribofuranose is a useful organic compound for research related to life sciences and the catalog number is TNU1317.

Nucleoside Derivatives - Bi-/Tricyclic nucleosides; Protected nucleosides w/NH2/OH open

D-myo-Inositol 4-mono-phos-phate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,4,6)-P3 (tested as the meso compound) is 9-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.

D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.[2]

1,2-O-Dilinoleoyl-3-O-Beta-D-Galactopyranosylracglycerol is a natural product used in life sciences research. The catalog number is T2A2400, and the CAS number is [111187-15-6].

2,5-Anhydro-D-glucitol-1,6-diphosphate acts primarily as a moderate stimulant of yeast Pyruvate Kinase and serves as an analog to the a-form, 2,5-anhydro-D-mannitol 1,6-bisphosphate, which is a potent allosteric activator of Pyruvate Kinase [1].