dc1

DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065.

LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).

DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 values of Ramos, Namalwa, HL60 / s

A18-Iso5-2DC18 (compound A18), a lipidoid, enhances mRNA protein expression and induces a robust immune response [1].

Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).

Iso5-2DC18, a lipid, is utilized in the synthesis of amine-containing lipids, which are instrumental in mRNA delivery, activation of the stimulator of interferon genes (STING) pathway, and demonstration of anti-tumor immunity [1].

A2-Iso5-4DC19, a lipidoid compound, effectively facilitates the delivery of agents, including polynucleotides, to cells [1].

A12-I20-2DC18, an ionizable cationic lipid, serves as an effective mRNA delivery vehicle [1].

YTHDC1-IN-1 (compound 40) serves as an effective inhibitor of YTHDC1, exhibiting a dissociation constant (Kd) of 49 nM. This compound plays a crucial role in cancer research.

DC10SMe is a DNA alkylating agent that can be used in the synthesis of antibody-drug conjugates (ADC). The IC50 of DC10SMe for Ramos, Namalwa and HL60 / s cancer cells were 15 pM, 12 pM and 12 pM, respectively.

SPPHPSPAFSPAFDNLYYWDQ is a multi-epitope class II rat HER2 neu peptide used in the investigation of class II HER2-DC1 vaccine studies [1].

SPPHPSPAFSPAFDNLYYWDQ TFA is a multi-epitope, class II rat HER2/neu peptide designed for research on the class II HER2-DC1 vaccine [1].

IRGRILHDGAYSLTLQGLGIH TFA, a multi-epitope class II rat HER2/neu peptide, is utilized in the study of class II HER2-DC1 vaccines [1].

DC41 is a derivative of DC1. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylating agents, used for targeted treatment of cancer.

IRGRILHDGAYSLTLQGLGIH is a multi-epitope class II rat HER2 neu peptide used in HER2-DC1 vaccine research studies [1].

DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used for targeted treatment of cancer.

The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then ade