decitabine

Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.

2'-Deoxycytidine is one of the major nucleosides of DNA consisting of cytosine and deoxyribose and inhibits the biological effects of bromodeoxyuridine (Brdu). The nucleoside consists only of a pentose sugar attached to a purine or pyrimidine base and has no phosphate group. When N1 is attached to C1 of deoxyribose, deoxyribosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), and deoxycytidine triphosphate (dCTP). cTP is the source of cytosine in RNA (ribonucleic acid) and deoxycytidine triphosphate (dCTP) is the source of deoxycytidine in DNA (deoxyribonucleic acid). Itaconic acid is a polymer.

Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.