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By Target- Apoptosis
- PLK(1)
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Results for "
dihydropteridinone
" in TargetMol Product Catalog- Inhibitors & Agonists2
Volasertib
Cited
BI 6727
T6019755038-65-4
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2 PLK3 (IC50s: 5 56 nM).
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CitedVolasertib trihydrochloride
BI6727trihydrochloride
T41100946161-17-7
Volasertib (BI 6727) trihydrochloride is a dihydropteridinone derivative that potently and selectively inhibits Polo-like kinase 1 (PLK1), PLK2, and PLK3, acting as an orally active ATP-competitive inhibitor with an IC50 of 0.87 nM against PLK1, 5 nM against PLK2, and 56 nM against PLK3. Its mechanism includes inducing mitotic arrest and apoptosis, with significant antitumor activity observed in various cancer models.
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