dnp-peg4-acid

DNP-PEG4-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation leveraging the ubiquitin-proteasome system within cells.

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

4-Methyl-4-(methyldisulfanyl)pentanoic acid is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and is designed to be cleavable.

DNP-NH-PEG2-C2-acid is a PEG-based linker for PROTACs, which connects two essential ligands critical for PROTAC molecule formation, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-derived PROTAC linker applicable for the synthesis of PROTACs [1].

4-Boc-amino-22-dimethylbutyric acid is an alkyl ether-derived PROTAC linker, suitable for PROTAC synthesis.

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl ether-based linker suitable for PROTAC synthesis [1].

4-Bromobutylphosphonic acid is an alkyl chain-derived PROTAC linker used for the synthesis of PROTACs [1].

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

4-Maleimidobutyric acid, an alkyl chain-derived PROTAC linker, facilitates the synthesis of PROTACs[1].

DNP-PEG6-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, thereby enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DNP-PEG12-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

Phenyl-glutarimide 4'-oxyacetic acid, a carboxylic acid-functionalized cerebellar ligand, is utilized in developing PROTAC deactivators due to its superior hydrolytic stability and efficacy. This compound exhibits enhanced binding to PROTAC, [1].