ec-19

EC-19 induces differentiation of EC cells and directs the formation of epithelial-like derivatives.

RAD51-IN-8, a new RAD51 binder, is a RAD51-BRCA2 inhibitor that disrupts the RAD51 BRCA2 protein-protein interaction in the micromolar range. This protein-protein interaction (PPI) inhibitor also demonstrates inhibitory activity for H4A4 with an EC50 value of 19 μM [1].

Antifungal agent 19 demonstrates potent antifungal activity (EC50 = 0.72 μM).

5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced hyperactivity [1].

Compound 19, a selective A3 Adenosine Receptor (A3AR) agonist (K i : 22.1 nM), effectively stimulates β-arrestin2 recruitment with an EC 50 value of 4.36 nM. This compound is utilized in research pertaining to inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, and other chronic conditions [1].

Influenza virus-IN-2 (compound 19) is a potent inhibitor of influenza A virus with anti-influenza activities, exhibiting a CC50 of 150.85 μM and an EC50 of 2.58 μM. Concentration-dependently, Influenza virus-IN-2 inhibits the PAN endonuclease with an EC50 of 489.39 nM [1].