Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, exhibiting IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors when transfected into human cells. This compound confers neuroprotection against NMDA-induced toxicity and has demonstrated anxiolytic- and antipsychotic-like properties [1].

Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).

Talaglumetad hydrochloride is a prodrug of Eglumegad which is the potent and selective agonist of the type II metabotropic glutamate receptor (mGluR2/3) to treat with psychiatric disorders.