en 6

6-(4-Hydroxyphenyl)-2-methylhept-2-en-4-one is a useful organic compound for research related to life sciences and the catalog number is T123873.

6-(4-Hydroxy-3-methylphenyl)-2-methylhept-2-en-4-one is a natural product for research related to life sciences. The catalog number is TN3141 and the CAS number is 949081-05-4.

11-Hydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN2584 and the CAS number is 74635-87-3.

Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) is a natural product for research related to life sciences. The catalog number is TN6498 and the CAS number is 1309929-72-3.

3,5,7-Trihydroxy-p-menth-1-en-6-one, 5-Tigloyl, 3 is a useful organic compound for research related to life sciences and the catalog number is T130192.

5-Hydroxy-1,7-diphenylhept-6-en-3-one is a natural product for research related to life sciences. The catalog number is TN6357 and the CAS number is 155239-30-8.

1,7-Bis(4-hydroxyphenyl)hept-6-en-3-ol is a natural product sourced from Alpinia galanga.

(S,E)-2-Methyl-6-(p-tolyl)hept-3-en-2-ol is a useful organic compound for research related to life sciences and the catalog number is T125520.

8-Oxoeremophil-6-en-12-oic aicd is a useful organic compound for research related to life sciences and the catalog number is T126063.

4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one is a natural product for research related to life sciences. The catalog number is TN2994 and the CAS number is 170380-68-4.

1,7-Bis(4-hydroxyphenyl)hept-6-en-3-one is a natural product for research related to life sciences. The catalog number is TN2514 and the CAS number is 1251830-57-5.

5α,8α-Epidioxyergost-6-en-3β-ol is a useful organic compound for research related to life sciences and the catalog number is T124161.

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate is a useful organic compound for research related to life sciences. The catalog number is T65075 and the CAS number is 17110-51-9.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one is a natural product

4|A,6|A-Dihydroxyeudesm-11(13)-en-12,8|A-olide is a natural product for research related to life sciences. The catalog number is TN3068 and the CAS number is 35001-19-5.

3-Hydroxy-p-menth-1-en-6-one is a natural product for research related to life sciences. The catalog number is TN5861 and the CAS number is 61570-82-9.

9alpha,11,12-Trihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3331 and the CAS number is 192566-65-7.

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

1-(3,4-Dihydroxyphenyl)-7-(4-hydroxyphenyl)hept-6-en-3-ol is a natural product used in life sciences research. The catalog number is TN2471 and the CAS number is 1206788-61-5.

9alpha,11-Dihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3332 and the CAS number is 127681-58-7.

Building block - others

Intermediate and Building Blocks - Nucleophile; Scaffolds and Templates

Sulcatone (6-Methyl-5-hepten-2-one) is an alarm/panic pheromone produce by ant species.

BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt.

Prosaikogenin F ((2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol) is a natural product with anticancer and hemolytic properties [1].

Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries known as pentahydroxy bile acids, alcohols, and derivatives. Polyporusterone B Polyporusterone B has an inhibitory effect on free radical-induced lysis of red blood cells (hemolysis).

1,8-Dihydroxy-p-menth-3-en-2-one is a natural product for research related to life sciences. The catalog number is TN5870 and the CAS number is 1392224-56-4.

(1beta,3beta,25S)-3-Hydroxyspirost-5-en-1-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-xylopyranoside is a natural product

6β-Ethoxy-8β,10β-dihydroxyeremophil-7(11)-en-12,8α-olide is a useful organic compound for research related to life sciences and the catalog number is T125285.

9-((1R,4S)-4-(tert-Butoxymethyl)cyclopent-2-en-1-yl)-N6-cyclopropyl-9H-purine-2,6-diamine is a useful organic compound for research related to life sciences and the catalog number is T64644.

(1R,5R)-4,6,6-Trimethylbicyclo[3.1.1]hept-3-en-2-one is a useful organic compound for research related to life sciences and the catalog number is T65496.

6α-Hydroxystigmast-4-en-3-one is a useful organic compound for research related to life sciences and the catalog number is T124266.

6β,8-Dihydroxyeremophil-7(11)-en-12,8-olide is a useful organic compound for research related to life sciences and the catalog number is T124600.

Compound 2, or 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide, is an ent-kaurene diterpenoid extracted from Rubescens rubescens. This compound exhibits cytotoxic activity against various cell lines, including EC-1, U87, A549, MCF-7, and HeLa, with IC50 values of 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, and 462.13 μM, respectively, as well as 180.09 μM against another unspecified line [1].

Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and Pfeiffer.

KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential for the research of multiple autoimmune diseases[1][2]. KZR-616 also inhibits MECL-1 subunit (IC50=623 nM) and constitutive proteasome β5 subunit (IC50=688 nM). KZR-616 maintains LMP7 and LMP2 selective inhibition in MOLT-4 cells. KZR-616 (250 nM) shows a comparable cytokine inhibition profile peripheral blood mononuclear cells (PBMC)[1].KZR-616 is an immunoproteasome-selective inhibitor identified based on the optimization of ONX-0914 and PR-924 [3]. KZR-616 (5 mg/kg; i.v.; dosing was repeated on days 6, 8, 11, and 13) shows efficacy in the anticollagen antibody induced arthritis (CAIA) model[1]. [1]. Johnson HWB, et al. Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem. 2018 Dec 27;61(24):11127-11143. [2]. Muchamuel T, et al. FRI0296 Kzr-616, a selective inhibitor of the immunoproteasome, blocks the disease progression in multiple models of systemic lupus erythematosus (SLE). Annals of the Rheumatic Diseases 2018;77:685. [3]. Xi J, et al. Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases. Eur J Med Chem. 2019;182:111646.

1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one is a natural product of Alpinia, Zingiberaceae. The catalog number is TN2512 and the CAS number is 1083200-79-6. 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one can be used as a reference standard.

Dammar-20(21)-en-3,24,25-triol is a natural product for research related to life sciences. The catalog number is TN3755 and the CAS number is 55050-69-6.

Chlolest-5-en-3β-tosylate; Cholest-5-en-3-ol (3β)-(4-methylbenzenesulfonate) is a useful organic compound for research related to life sciences. The catalog number is TNU0846 and the CAS number is 1182-65-6.