euphorbia factor pe 1

Complement factor D-IN-1 is a potent and selective small-molecule reversible Factor D inhibitor, with IC50 values of 0.006 μM in the FD Thioesterolytic Fluorescent Assay and 0.05 μM in the MAC Deposition Assay.

NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM.

1-Myristoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid that induces transient intracellular calcium increases in PC12 cells. Serum levels of 1-myristoyl-2-hydroxy-sn-glycero-3-PE are elevated in patients with malignant breast cancer compared to healthy controls.

1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid containing stearic acid and adrenic acid at the sn-1 and sn-2 positions, respectively. Levels of 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus [1].

Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in cellular membranes. It has been used in studies involving the biosynthesis of anandamide via the phospholipase A2 (PLA2) and lysoPLD pathways. PLPE can also be used as a specific substrate to assess the activity of sPLA2-IIA in the presence of other phospholipids.

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid with stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position, produced by oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). At concentrations of 0.6 and 0.9 μM, it increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

Factor XI-IN-1 is an inhibitor of factor XI activation (EC50: 25.14 nM).

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PE serves as an internal standard for quantifying 1-palmitoyl-2-hydroxy-sn-glycero-3-PE, a lysophospholipid naturally found to inhibit L. donovani promastigotes growth (GI50= 8 µM). Its levels are reduced in mice after alcohol-induced liver damage, in hepatocellular carcinoma mouse xenografts, and in humans following a rigorous three-day exercise regimen of 2.5 hours running daily and 14 hours post-regimen. This compound is also applied in measuring saturated lysophosphoethanolamines, highlighting its broad utility in biochemical research and disease model studies.

Mating Factor α (1-6), a compound secreted by α-mating type cells of Saccharomyces cerevisiae, functions as an inhibitor of DNA synthesis initiation in these cells [1].

Atrial natriuretic factor (1-28) from both human and porcine sources is a potent suppressor of pro-opiomelanocortin (POMC) mRNA, exerting only a modest inhibitory effect on βEP-LI release.

Elongation factor P-IN-1, a potent elongation factor P (EFP) inhibitor and β-lysine derivative compound, affects E. coli proliferation rate[1].

Factor B-IN-1 is a Factor B inhibitor (IC50 = 43 nM) and is an analog of compound 13. It is used to inhibit complement pathway factor B and has improved pharmacokinetic properties (oral availability in rats and dogs).

Euphorbia factor L25 is a useful organic compound for research related to life sciences and the catalog number is T125089.

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid containing stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position, formed in human peripheral monocytes activated by the calcium ionophore A23187 through direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes.

Euphorbia factor L7a is a diterpene found in the seeds of Morinda citrifolia.

Epigenetic factor-IN-1 (40569Z) is an inhibitor that exhibits potent binding affinity for SIRT7 and is utilized in the study of liver cancer [1].

1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE, a plasmalogen, incorporates 1(Z)-hexadecenoic acid and palmitic acid at the sn-1 and sn-2 positions, respectively.

1-1(Z)-Hexadecenyl-2-palmitoyl-d9-sn-glycero-3-PE serves as an internal standard for quantitating 1-1(Z)-hexadecenyl-2-palmitoyl-sn-glycero-3-PE, which is a plasmalogen incorporating 1(Z)-hexadecanoic acid and palmitic acid at the sn-1 and sn-2 positions respectively, in analyses performed using GC- or LC-MS.

1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-PE, a phospholipid comprising palmitic acid (at the sn-1 position) and docosahexaenoic acid (at the sn-2 position), is present in the nucleus of mouse liver but absent from mitochondria. Notably, its levels in pre-term infant plasma are lower compared to those in maternal or fetal plasma.

Brain-derived acidic fibroblast growth factor (brain-derived aFGF) (1-11) is a peptide fragment of brain-derived aFGF. Brain-derived aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. aFGF (1-11) corresponds to amino acid residues 1-11 of the full length peptide.

Factor VII-IN-1 (example 43) exhibits anticoagulant activities as a potent factor VII (FVII) inhibitor with an IC50 value of 1.1 μM [1].

Euphorbia factor L24 is a useful organic compound for research related to life sciences and the catalog number is T125685.

1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid that inhibits the growth of L. donovani promastigotes (GIC50 = 8 uM). Its serum levels are decreased in mouse models of alcohol-induced liver injury and hepatocellular carcinoma and in humans following an exercise regimen of 2.5 hours of running for three days. It has also been used as an internal standard for quantifying saturated lysophosphoethanolamines.

Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA), is the primary circulating form of ANP in rats and significantly inhibits Ang II-stimulated secretion of endothelin-1.

Euphorbia factor L8 is a diterpene from Morinda citrifolia seeds.

1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PE, a phospholipid comprising palmitic acid and arachidonic acid at the sn-1 and sn-2 positions respectively, is identified in egg yolk and isolated rat retina.

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed

18:1 PEG-PE, a polyethylene glycol/phosphatidylethanolamine conjugate, serves as a vehicle for drug delivery [1].

1-Palmitoyl-d9-2-palmitoyl-sn-glycero-3-PE serves as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PE (1,2-DPPE) using GC- or LC-MS. 1,2-DPPE, a prevalent PE (phospholipid), contains C16:0 fatty acids at the sn-1 and sn-2 positions and is essential in the inner plasma membrane leaflet. This compound forms a condensed lipid monolayer with cholesterol through tight hydrogen bonding between 1,2-DPPE headgroups, enhancing membrane fluidity to support transport and signaling.

Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF. bFGF is a peptide produced in bovine brain that is protective in a rat model of pressure-induced retinal ischemia. bFGF (1-24) corresponds to amino acid residues 1-24 of the full length peptide.

Euphorbia factor L9 is a useful organic compound for research related to life sciences and the catalog number is T126086.

Euphorbia factor L22 is a useful organic compound for research related to life sciences and the catalog number is T125686.

Deoxy euphorbia factor L1 is a natural product found in the seeds of Euphorbia lathyris L

Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24), a synthetic peptide with anti-bacterial and anti-HBV properties, is utilized in infectious and immune disease research [1].

Euphorbia factor L7b,a natural product obtained from the herbs of Euphorbia pekinensis Rupr.

PE(18:1(9Z)/0:0) is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. PE(18:1(9Z)/0:0) induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner. PE(18:1(9Z)/0:0) increases the production of IL-4 and IL-2, but not IFN-γ. In mouse serum, PE(18:1(9Z)/0:0) (1 μg/animal) induces the T helper 2 response. PE(18:1(9Z)/0:0) levels increase in interscapular brown adipose tissue in mice following three-day cold exposure.

Euphorbia Factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation.

Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.

20-O-Acetylingenol-3-angelate (Euphorbia factor Pe1) is a natural compound found in the leaves and stems of the plant Inga. It has a variety of biological activities including tumor growth inhibition, anti-inflammatory, antifungal and antioxidant effects.