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fm 381

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  • Inhibitors & Agonists
    3
    TargetMol | Activity
FM-381
FM381
T50912226521-65-7
FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
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FM-479
T223332226521-64-6
FM-479, an FM-381 structural analog, exhibits no inhibitory potency against JAK3 or other kinases when used at the FM-381 effective dosing range (100-300 nM). FM-479 is used as a negative control for FM-381.
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8-10 weeks
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FM-476
T31832
FM-476 is a negative control for FM-381.
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