fmoc-n-peg-ch2cooh

Fmoc-N-amido-PEG-CH2COOH (MW 5000), a PEG-based PROTAC linker, is used in PROTAC synthesis [1].

Fmoc-N-amido-PEG-CH2COOH (MW 3400) is a PEG-based PROTAC linker used in PROTAC synthesis[1].

Fmoc-N-amido-PEG2-alcohol is a PEG-based linker for PROTACs [which joins two essential ligands], crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized E3 ligase ligand-linker conjugate, incorporating the cereblon ligand from Pomalidomide and a linker used in PROTAC technology. It facilitates targeted protein degradation by modulating E3 ligase activity, thereby enabling the selective elimination of specific proteins of interest.

Fmoc-N-PEG24-acid is a PEG-based linker for PROTACs, crucial for connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl ether-based linker for PROTACs, facilitating the connection of two essential ligands critical for forming PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Fmoc-N-bis-PEG3-NH-Boc is a cleavable ADC linker compound with three PEG units, used in the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-N-amido-PEG20-acid is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs[1].

Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-N-PEG3-CH2-NHS ester is a PEG-based PROTAC linker that aids in the synthesis of PROTACs[1].

Fmoc-N-amido-PEG23-acid is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Fmoc-N-amido-PEG36-acid is a polyethylene glycol (PEG)-based linker used in PROTAC synthesis, designed to construct bifunctional molecules that recruit target proteins to an E3 ubiquitin ligase for degradation[1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

Fmoc-N-amido-PEG7-acid, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Ph-Bis(C1-N-(C2-NH-Boc)2) is a versatile alkyl chain-derived linker used in the synthesis of PROTACs [1].

N-Fmoc-N'-(azido-PEG4)-L-Lysine is an alkyl ether-based PROTAC linker frequently used in the synthesis of PROTACs[1].