gastric mucosa

Spizofurone (Espizofurona) has antiulcer activity, protective effect on the gastric mucosa of rats, and can increase alkaline secretion in isolated bullfrog duodenal mucosa.

Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.

Esaprazole (C/63) has a dose - dependent cellular protective effect on the human gastric mucosa.

Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.

Rotraxate (TEI 5103) is a compound with anti-ulcer properties that is effective when taken orally. It enhances blood circulation to the gastric mucosa and supports its structural integrity. Rotraxate is useful for exploring the protective effects of medications on the gastric mucosa, particularly in research focused on preventing or treating gastric ulcers through direct action on the gastric mucosa.

Sucrose octasulfate, a constituent of sulfoaluminum, promotes the release of somatostatin-like immunoreactivity (SLI) through direct interaction with D cells within the gastric mucosa, thereby exerting its ulcer-healing effects by facilitating the secretion of endogenous gastric somatostatin. This compound is utilized in anti-gastric ulcer research [1].

Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2.

Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response.

CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa.

Glycine-pentagastrin can enhance gastric mucosal defence mechanisms against acid and protect the gastric mucosa from experimental injury.

PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig gastric mucosa & cerebral cortex in the peripheral and central nervous systems.

6-Gingediol (compound 13) is a pungent component derived from ginger, noted for its potential antiserotonergic properties and protective effects on the gastric mucosa. Notably, 6-Gingediol exhibits no nasal irritation at concentrations below 10 μM, while significantly pronounced nasal irritation occurs at concentrations exceeding 100 μM and up to 1000 μM.

Pentagastrin (ICI-50123) is a synthetic polypeptide that mimics the effects of gastrin when administered parenterally, influencing the secretion and synthesis of salivary proteins.

S-Diclofenac is a novel NSAID formed by linking diclofenac to an H2S-releasing moiety. S-Diclofenac spares the gastric mucosa of injury despite markedly suppressing prostaglandin synthesis [1].

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act

Xenin is a 25 amino acid peptide that has been identified in human gastric mucosa in the search for a counterpart to the amphibian octapeptide xenopsin.