VGSCs-IN-1 is a potent VGSC inhibitor, a 2-piperazine analog of Riluzole that exhibits good blocking activity on Nav1.4.VGSCs-IN-1 can be used to study cellular excitability disorders.

Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.

2-Fluoropalmitic acid, functioning as an acyl-CoA synthetase inhibitor, is a potential anti-glioma agent. It diminishes the viability and stem-like characteristics of glioma stem cells (GSCs) and hinders the proliferation and invasion of glioma cell lines [1].

CP681301 is a potent inhibitor of CDK5 with antiproliferative activity. CP681301 exhibits anti-tumor activity in Drosophila. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in Glioma stem cells (GSCs). CP681301 reduces self-renewal in mouse glioma xenografts [1].

GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.

Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.

Topotecan hydrochloride hydrate is an orally active Topoisomerase I inhibitor with anticancer properties. topotecan hydrochloride hydrate is capable of blocking the cell cycle in G0/G1 and S phases and inducing apoptosis.