gsk-2140944

Gepotidacin hydrochloride, also known as GSK-2140944 hydrochloride, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin hydrochloride is a novel antibacterial drug candidate. Gepotidacin hydrochloride Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin hydrochloride is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, Gepotidacin hydrochloride inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

Gepotidacin is a novel triazaacenaphthylene inhibitor of bacterial type II topoisomerase.

CM-546 is the trans-isomer of CM-414, and a dual inhibitor of PDE5 and HDACs.

Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.