ha 44

Abametapir (BRN 0123183), a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development.

Antitumor Agent-108 (Compound 5), an inhibitor of the Hyaluronic Acid (HA)-CD44 interaction, effectively disrupts cancer spheroid integrity and exhibits antiproliferative activity against cancer cells [1].

Antitumor agent-109 (compound 6) is a dual-function inhibitor targeting hyaluronic acid and CD44, molecules implicated in tumor progression and invasion, and exhibits potent antitumor activity by inhibiting MDA-MB-231 cells with an EC50 of 0.59 µM [1].