herbicidal

Herbicidal agent 1 ((S)-6q) exhibits superior activity compared to its racemic form [1].

Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.

Imazapic (Imazamethapyr) has a broad herbicidal spectrum and controls a variety of annual grass weeds.

PDS-IN-1 potently inhibits Oryza sativa phytoene desaturase (OsPDS), exhibiting herbicidal activity [1].

DHDPS-IN-1 (compound 8) is an inhibitor of dihydrodipicolinate synthase (DHDPS) with an IC50 of 39 μM, potentially useful in antibacterial and herbicidal applications [1].

Phytoene desaturase-IN-1, a potent inhibitor of phytoene desaturase (PDS) with a dissociation constant (Kd) of 65.9 μM, acts through π−π stacking interaction with the Phe301 residue. This compound exhibits a broad spectrum of post-emergence herbicidal effects by inducing a reduction in PDS mRNA, and accumulation of phytoene and reactive oxygen species (ROS) in albino leaves, suggesting its utility in agricultural production [1].

Phosalacine, isolated from Kitasatosporia phosalacinea, is a new herbicidal antibiotic that contains phosphinothricin.

PPO-IN-3 (Compound 8ad) is a potent PPO inhibitor with a Ki value of 0.67 nM and demonstrates post-emergence herbicidal properties suitable for weed management [1].

QPP-I-6, an inhibitor of acetyl-coenzyme A carboxylase (ACCase), exhibits herbicidal activity by inducing cell membrane permeability [1].

SDH-IN-12 (compound 9b), a succinate dehydrogenase inhibitor, shows activity against S. sclerotiorum and C. arachidicola, with respective EC50 values of 0.97 and 2.07 μM. The compound demonstrates no significant herbicidal effects on monocotyledonous and dicotyledonous plants [1].

PPO-IN-7 (compound 35), a potent protoporphyrinogen oxidase (PPO) inhibitor, exhibits herbicidal activity [1].

Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herboxidiene (0.05 μM) inhibits HIF-1α mRNA splicing and reduces HIF-1α protein levels in HepG2 cells grown under hypoxic conditions. It also inhibits splicing of p27Kip mRNA in HeLa cells in a concentration-dependent manner via interaction with the SAP155 subunit of the SF3b complex.[2] Herboxidiene (0.1 and 1 μM) increases LDL receptor promoter-driven transcription in a cell-based reporter assay.[5] It also exhibits herbicidal activity against wild buckwheat, morning glory, maize, hemp sesbania, and rapeseed when applied at 0.069 kg/hectare.[1]

(9S)-Macrocidin B exhibits a less potent herbicidal activity compared to macrocidin A.

Antimalarial agent 17, functioning both as an antimalarial agent and a herbicide, inhibits photosystem II and demonstrates post-emergence herbicidal efficacy comparable to commercial herbicides [1].

Brassicanate A sulfoxide, isolated from Brassica oleracea [1], exhibits herbicidal properties by inhibiting the biosynthesis of essential amino acids in plants. It operates by binding to key enzymes such as dihydroxyacid dehydratase (DHAD), hydroxymethylpyruvate dioxygenase (HPPD), acetolactate synthase (ALS), PYL family proteins, and transport inhibitor response 1 (TIR1), thereby reducing their enzymatic activity.

HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassing mesotrione's IC50 of 0.283 μM, and demonstrates excellent herbicidal efficacy against both broadleaf and monocotyledonous weeds [1].

Transketolase-IN-3, a potent inhibitor of transketolase (TK), exhibits herbicidal activity by effectively suppressing Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). This compound holds potential for herbicide research applications [1].