hpk1in19

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)

HPK1-IN-19 is an inhibitor of hematopoietic progenitor kinase 1 (HPK1).

C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]

Enpp-1-IN-19 (compound 29f) is an orally active inhibitor of ENPP1 that effectively blocks cGAMP hydrolysis with an IC50 of 68 nM. It not only enhances anti-PD-L1 responses and curtails tumor growth in CT26 syngeneic models but also boosts STING-mediated type I interferon responses. Additionally, Enpp-1-IN-19 fosters immune memory and aids in preventing tumor recurrence [1].

HIV-1 inhibitor-19 is a potent inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRTI) that targets L100I, K103N, and V106A F227L mutant strains with EC50s of 7.3 nM, 9.2 nM, and 21.0 nM, respectively.

Galanin (1-19), human, represents the fragment encompassing amino acids 1 to 19 of the human galanin neuropeptide. Galanin (GAL) is known for its extensive distribution and multifaceted biological roles, such as regulating hormone secretion, providing antinociceptive effects, and altering feeding behavior.

CDK8 19-IN-1 is a selective, orally bioavailable dual inhibitor of CDK8 and CDK19, with IC50 values of 0.46 nM for CDK8, 0.99 nM for CDK19, and 270 nM for [CDK9].

Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate p