hydroxy-peg-5-acid

Hydroxy-PEG5-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].

Hydroxy-PEG2-C2-sulfonic acid, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Hydroxy-PEG16-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Hydroxy-PEG4-acid, a non-cleavable 4-unit PEG ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Hydroxy-PEG12-acid, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Hydroxy-PEG1-acid is a non-cleavable 1-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Hydroxy-PEG6-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Hydroxy-PEG3-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functi

5-Maleimidovaleric acid, a cleavable linker for antibody-drug conjugates (ADCs) synthesis, is employed as an ADC linker[1].

5-endo-BCN-pentanoic acid, an alkyl chain-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Hydroxy-PEG2-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Fmoc-5-aminopentanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.