il-18rb

IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.

Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs. It augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells. In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils.

IL-18 Protein, Rhesus, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.7 kDa and the accession number is Q9BGI5.

IL-18 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 48.6 kDa and the accession number is Q14116.

Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.

IL-36 gamma Protein, Human, Recombinant (aa 18-169, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.1 kDa and the accession number is Q9NZH8-1.

IL-36 gamma Protein, Human, Recombinant (aa 18-169) is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is Q9NZH8-1.

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation.

IL-18 Protein, Canine, Recombinant (His) is expressed in E. coli.

IL-18 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is Q14116-1.

IL-18RAP, also known as IL-18Rβ or IL-1R7, is component of IL-18 receptor complex and its interactions with IL-18R1 mediate signal transduction initiated by IL-18 although it does not directly bind IL-18 in vitro.