intractable

Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.

Nafimidone shows anticonvulsant activity in a rat model of amygdala epilepsy and can be used in the treatment of chronic intractable epilepsy.

Cav 3.2 inhibitor 2 is an inhibitor of Cav3.2 T-type Ca2+channels with an IC50=0.09339 μM at a constant potential of -80 mV. Cav 3.2 inhibitor 2 exhibits potent inhibition of T-channel-dependent somatic and visceral pain in mice. inhibitor 2 can be used to study intractable pain.

Compound I16 (ROS inducer 2) is a potent inducer of Reactive Oxygen Species (ROS) with an effective concentration (EC 50) of 3.43 μg/mL demonstrated in vitro. It exhibits exceptional bioactivity in vivo against Xanthomonas axonopodis pv. citri and has potential as a bactericidal agent for investigating intractable plant bacterial diseases [1].