jak3in11

JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently binds to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T-cell proliferation which is a promising tool for studying autoimmune diseases [1].

JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.

9(11),12-Oleanadien-3-ol is a natural product from Euonymus maackii.

[Ala1,3,11,15]-Endothelin (TFA) is a highly selective for endothelin A (ETA) and endothelin B (ETB) receptor.[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ET

JAK-2 3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms, exhibiting remarkable potency with Ki values below 250 nM for both isoforms.

20)abeotaxa-4(20),11-dien-10-one'>2alpha,7beta,13alpha-Triacetoxy-5alpha-cinnamoyloxy-9beta-hydroxy-2(3->20)abeotaxa-4(20),11-dien-10-one is a natural product for research related to life sciences. The catalog number is TN2840 and the CAS number is 322471-42-1.

3-Hydroxylanost-9(11)-24-dien-26-oic acid is a natural product for research related to life sciences. The catalog number is TN2949 and the CAS number is 129724-83-0.

3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-moderate antiproliferative activity ag

JAK HDAC-IN-3 (13a), a dual inhibitor of JAK and HDAC, exhibits IC50 values of 25.36 nM for JAK2, 0.2 μM for HDAC, and 0.43 μM for HDAC1, respectively [1].

Substance P (3-11), an SP fragment peptide capable of crossing the blood-brain barrier (BBB), induces contraction in guinea pig ileum and facilitates chemotaxis in human monocytes [1] [2] [5].

Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-, a lanosterane-type compound, can be isolated from Tu-Jin-Pi, the root bark of Pseudolarix kaempferi [1].

[Ala1,3,11,15]-Endothelin (53-63) (TFA) is a selective ET B agonist with IC50 values from 0.33 nM to 0.61 nM, indicating a high affinity for ET B receptors, and is used in vasoconstriction research.

JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid, a lanostanoid, is found in the basidiomycete Ganoderma applanatum from Sri Lanka.

3-Eudesmene-1beta,11-diol is a natural product for research related to life sciences. The catalog number is TN2933 and the CAS number is 658062-22-7.

3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.

3-hydroxy-12-oxochol-9(11)-en-24-oic acid is a useful organic compound for research related to life sciences and the catalog number is T131562.

3-O-Acetyl-11-hydroxy-beta-boswellic acid, the precursor of 3-O-acetyl-9,11-dehydro-beta-boswellic acid (a 5-lipoxygenase inhibitor),

(1R,6R,9R)-6,9,11-Trihydroxy-4,7-megastigmadien-3-one 11-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6201 and the CAS number is 289914-68-7.

4α,8β-Dihydroxy-3α-(2-hydroxy-3-acetoxy-2-methylbutyryloxy)eudesm-7(11)-en-12,8α-olide is a natural product for research related to life sciences. The catalog number is TN5399 and the CAS number is 1442989-33-4.

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

3-Acetyl-11-keto-ursolic acid (Compound 18), a triterpenoid derived from Eriobotrya japonica leaves, exhibits inhibitory activity against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and holds potential for anti-diabetes research [1].

3-Acetoxy-4,7(11)-cadinadien-8-one is a natural product for research related to life sciences. The catalog number is TN2916 and the CAS number is 104975-02-2.

JAK-2- 3-IN-3 (compound ST4j) is a potent inhibitor of JAK2 3, with IC50 values of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. It inhibits JAK2 autophosphorylation, induces apoptosis in a time- and dose-dependent manner, and can be used in lymph-derived diseases and leukemia research [1].

JAK-2 3-IN-2 (Compound 3h) is a potent dual inhibitor of JAK2 and JAK3, exhibiting inhibitory activity with IC50 values of 23.85 nM and 18.9 nM against JAK2 and JAK3, respectively [1].

JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.