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jnj40346527

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  • Inhibitors & Agonists
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Edicotinib
JNJ-527,JNJ-40346527
T151991142363-52-7
Edicotinib (JNJ-527) is a blood-brain-penetrating, orally active, selective CSF-1R inhibitor (IC50 value is 3.2 nM), with less inhibitory effects on KIT (IC50 value is 20 nM) and FLT3 (IC50 value is 190 nM). Edicotinib (JNJ-527) can block microglial proliferation and attenuate neurodegeneration, and can be used to study Alzheimer's disease and rheumatoid arthritis.
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R 93274
T70443155928-24-8
R 93274 is a radioiodinated 5-HT2A receptor antagonist.
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8-10 weeks
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