k-ras g-12c-in-2

K-Ras G12C-IN-2 is a covalent KRAS G12C inhibitor.

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

pGlu-K(-NBD)-Q-R-L-G-N-Q-W-A-V-G-H-L-M-N is a peptides

2’-beta-C-Methyl inosine (2’-C-Methylinosine) is an HCV RNA polymerase inhibitor with antiviral activity and is being studied for the treatment of hepatitis C virus infection.

2′-C-Methyl-6-O-methylinosine (2′-C-Methyl-6-O-methylinosine) is a hypoxanthine analog exhibiting diverse physical activities for researching various tumor diseases.

5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.

c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).

Protein kinase G inhibitor-2 exhibits antibacterial, antiviral, and antitumor activities.

K-Ras-IN-1, a K-Ras inhibitor, is characterized by its chemical formula C20H19ClN4O2S and is also known as N-[(1S)-3-cyclopropyl-1-[(6-fluoro-1H-benzimidazol-2-yl)sulfanyl]-2-oxo-1-(phenylmethyl)propyl]-4-fluorobenzenesulfonamide (compound [18, dashboard 819041] in brackets).

K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant, achieving 100% protein modification at 10 μM after 24 hours in vitro.

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of the oncogenic K-Ras(G12C) protein.

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).

K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ that binds to the farnesyl binding pocket of PDEδ (Kd of 8 nM).

C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.

4-Chloro-2-(2,6-dioxopiperidin-3-yl)-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione is a useful organic compound for research related to life sciences and the catalog number is T64660.

VEGFR-2 c-Met-IN-1 is a dual inhibitor of VEGFR-2 and c-Met, with IC50 values of 138 nM and 74 nM, respectively, demonstrating antitumor activity [1].

Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), shows potent inhibitory activity with an IC50 of 10.64 nM. By disrupting glutamine metabolism, it modulates cellular metabolites and elevates reactive oxygen species (ROS), exerting anticancer effects [1].

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66095 and the CAS number is 720720-96-7.

C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].

3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

Apigenin 6-C-(2-O-feruloyl)glucoside 8-C-glucoside is a useful organic compound for research related to life sciences and the catalog number is T126101.

Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][[5-[(dimethylamino)sulfonyl]-2-(1-methylethoxy-O)phenyl]methylene-C]ruthenium(II) is a useful organic compound for research related to life sciences and the catalog number is T66135.

C-Peptide 2, rat acetate is a proinsulin component of inhibiting glucose-induced insulin secretion, consisting of acetate and a polypeptide composed of 31 amino acid residues [1] [2].

2-Amino-6-chloro-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purine is a 2'-C-Methyl nucleoside; Halo-nucleoside.

Rev 2’-O-MOE-C(Bz)-5’-amidite; N4-Benzoyl-3'-O-(4,4’-dimethoxy trityl)-2'-O-(2-methoxyethyl)cytidine-5’-CED phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1531.

Nucleoside Derivatives - 2’-Modified nucleosides, 5-Modified pyrimidine nucleosides

3'-O-Me-C(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

Nucleoside Derivatives - Thio-nucleosides; 3’-Modified nucleosides

Nucleosides and Reagents - Fluoro-modified nucleoside; 2’-C-methyl nucleoside; ; 5-Modified pyrimidine nucleoside

N6-Methyl-2'-beta-C-ethynyl adenosine is a Nucleoside Derivative - 2'-Modified nucleoside, 6-Modified purine nucleoside.

K-Ras ligand-Linker Conjugate 4 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker, responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It has the potential to be used in synthesizing PROTAC K-Ras Degrader-1, which shows a degradation efficacy of ≥70% in SW1573 cells[1].

5'-O-Benzoyl-3'-O-(4-methoxybenzoyl)-2'-O,4'-C-methyleneuridine is a Nucleoside Derivative - LNA-related nucleoside.

1-(2-C-b-Methyl-b-D-ribofuranosyl)-5-nitropyridine-2(1H)-one is a Pyridine nucleoside; 2'-C-Methyl nucleoside.

2'-b-C-Ethynyladenosine is a Nucleoside Derivative - 2'-Modified nucleoside.

Nucleosides and Reagents - 4-Deoxypyrimidine nucleoside; 2’-C-Methyl nucleoside

2’-C-Methyl nucleoside; 2/6/8-modified nucleoside

DMT-2'-OMe-Bz-C is a 2'-O-Methyl nucleoside.

2-Amino-2'-C-methyladenosine is a 2'-C-Methyl nucleoside.

2'-O,4'-C-Methylenecytidine is a nucleoside derivative related to LNA.

2'-beta-C-Ethynyl inosine is a Nucleoside Derivative - 2'-Modified nucleoside.

5'-O-Benzoyl-2'-O,4'-C-methyleneuridine is a Nucleoside Derivative - LNA related nucleoside; Protected nucleoside with NH2/OH open.

2-O-Ethyl PAF C-16, a homolog of Platelet-activating Factor (PAF) and competitive ligand for the Platelet-activating Factor Receptor (PAFR), inhibits the binding of PAF antagonist WEB 2086 to PAFR with an IC50 of 21 nM [1].

2'-beta-C-Ethynyluridine is a Nucleoside Derivative - 2'-Modified nucleoside.

2'-C-Methyl-5-methyluridine is a 2'-C-Methyl nucleoside; 5-Modified pyrimidine nucleoside.

6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purine is a 2'-C-Methyl nucleoside and a halo-nucleoside.

1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.