kras g12cin2

Protein kinase G inhibitor-2 exhibits antibacterial, antiviral, and antitumor activities.

K-Ras G12C-IN-2 is a covalent KRAS G12C inhibitor.

PROTAC KRAS G12C degrader-2 (compound 432) acts as a bifunctional modulator, enhancing the hydrolysis of K-Ras protein. One end of this compound features a cereblon inhibitor of apoptosis proteins (IAP), while the other end contains a moiety that binds to KRAS [1].

FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a fluorescein isothiocyanate (FITC)-labeled segment of the HHV-2 Envelope Glycoprotein G encompassing amino acids 561 to 578. This immunodominant region of glycoprotein G (gG-2) exhibits reactivity with all herpes simplex virus type 2 (HSV-2) sera [1].

4-Methyl-6,7,8,9-tetrahydro-2H-pyrano[3,2-g]quinolin-2-one is a useful organic compound for research related to life sciences and the catalog number is T66960.

KRASG12C IN-2 (compound 17) is an orally active KRAS G12C inhibitor that effectively suppresses tumor growth in mice [1].

11R,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2593 and the CAS number is 62574-30-5.

VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent inhibitor of VEGFR-2 with an IC50 of 0.037 μM and demonstrates anti-tumor effects.

KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 μM, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.

SARS-CoV-2-IN-12, a potent inhibitor of the SARS-CoV-2-related 3C-like protease (K_i=32.1 pM), plays a crucial role in preventing SARS-CoV-2 viral replication, showcasing potential significance in COVID-19 research.

2’-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer suitable for oligonucleotide synthesis.

Compound 1059182-21-6 features a cyclic structure characterized by a nitrogen atom occupying an apex (corner) within the heterocycle. Its molecular scaffold integrates aromatic properties due to the presence of a conjugated system, while the inclusion of hydroxyl (-OH) groups confers reactive potential for subsequent modification. Additionally, a halogenated component, specifically a bromine atom, is attached to the aromatic ring, enhancing its propensity for undergoing further synthetic transformations.

2'-MOE-G(iBu)-3'-phosphoramidite is a Nucleoside Phosphoramidite;Nucleoside Derivative - 2'-Modified nucleoside;.

2-(2-Acetoxy-12-hydroxytridecyl)-4,6-dihydroxybenz is a useful organic compound for research related to life sciences. The catalog number is T126038 and the CAS number is 133361-20-3.

Rev 2'-O-MOE-G(iBu)-5'-amidite is a Nucleoside Phosphoramidite.

COX-2-IN-12 (compound 3b) is a potent and selective COX-2 inhibitor with an IC50 of 19.98 μM, demonstrating anti-inflammatory properties and safety in in-vivo acute toxicity studies [1].

Bcl-2-IN-12 (Compound 1) is a potent Bcl-2 inhibitor with an IC50 value of 6 nM, used in cancer research [1].

HHV-2 Envelope Glycoprotein G (552-574), an immunodominant region within glycoprotein G (gG-2), demonstrates reactivity with all herpes simplex (HSV-2) sera [1].

SARS-CoV-2 Mpro-IN-12 (compound D026) is an inhibitor of the main protease (Mpro) of SARS-CoV-2, demonstrating antiviral properties [1].

2'-O-Propargyl G(iBu)-3'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - 2'-Modified nucleoside.

KRas G12C inhibitor 2 is a compound specifically designed to inhibit the KRas G12C mutation.

5-(2-Acetoxy-12-hydroxytridecyl)-1,3-benzenediol is a useful organic compound for research related to life sciences. The catalog number is T126037 and the CAS number is 133361-21-4.

11S,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2594 and the CAS number is 62623-86-3.

3'-O-Me-G(iBu)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

Kras binder 12 can be used in studies about Ras.

Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 ＞10 μM, for the KRAS G13D mutant [1].

KRAS G12D inhibitor 12 is an effective inhibitor of KRAS G12D. The Ras protein family is an important intracellular signaling molecule, which plays an important role in growth and development. KRAS G12D inhibitor 12 has the potential to perform KRAS G12D-mediated cancer studies.

1-Palmitoyl-2-12-PAHSA-3-oleoyl-sn-glycerol, an endogenous triacylglycerol, comprises palmitic acid (at the sn-1 position), the fatty acid ester of hydroxy fatty acids (FAHFA), 12-PAHSA (at the sn-2 position), and oleic acid (at the sn-3 position). Identified in the lipid extract of mouse adipose tissue, this triacylglycerol demonstrates that levels of FAHFA-containing triacylglycerols are over 100-fold higher than those of non-esterified FAHFAs, suggesting their role as intracellular storage reservoirs for FAHFAs.

3'-O-MOE-G(iBu)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

(Rac)-Phorbol-12-(2-methylbutyrate), a natural product, can be isolated from croton oil [1].