losartan (d4 carboxylic acid)

Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist.

4-Trifluoromethylsalicylic acid-13C6 is 13C-labeled 4-Trifluoromethylsalicylic acid, mainly used as a quantitative tracer in drug development. 4-Trifluoromethylsalicylic acid is also a platelet aggregation inhibitor.

Ezetimibe-d4 Phenoxy ß-D-Glucuronide is a deuterated compound of Ezetimibe Phenoxy ß-D-Glucuronide. Ezetimibe Phenoxy ß-D-Glucuronide has a CAS number of 190448-57-8.

Deoxycholic-2,2,4,4-d4 Acid is a deuterated compound of Deoxycholic-2,2,4,4 Acid.

Salicylic Acid-d4 is a deuterated compound of Salicylic Acid.

(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid is a deuterated compound of (4-Hydroxy-3-methoxyphenyl)acetic Acid. (4-Hydroxy-3-methoxyphenyl)acetic Acid has a CAS number of 306-08-1. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Caspofungin-d4-Dicarboxylic acid is a deuterated compound of Caspofungin-Dicarboxylic acid. Caspofungin-Dicarboxylic acid has a CAS number of 162808-62-0.

Valproic Acid-d4 is a deuterated compound of Valproic Acid. Valproic Acid has a CAS number of 99-66-1. Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Taurodeoxycholic Acid-d4 Sodium Salt is a deuterated compound of Taurodeoxycholic Acid Sodium Salt. Taurodeoxycholic Acid Sodium Salt has a CAS number of 1180-95-6. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. and it inhibits various inflammatory responses

Tauroursodeoxycholic-d4 Acid is a deuterated compound of Tauroursodeoxycholic Acid. Tauroursodeoxycholic Acid has a CAS number of 14605-22-2. Tauroursodeoxycholate, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.

Phthalic acid, bis-propyl ester-d4 is a deuterated compound of Phthalic acid, bis-propyl ester. Phthalic acid, bis-propyl ester has a CAS number of 131-16-8.

Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide. Enzalutamide carboxylic acid D6 is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid).

Losartan D4, the deuterium-labeled version of Losartan, functions as an angiotensin II receptor antagonist. It inhibits the interaction between angiotensin II and AT1 receptors by competing for binding, achieving an IC50 value of 20 nM.

Glycochenodeoxycholic Acid-d4 is a deuterated compound of Glycochenodeoxycholic Acid.

Enzalutamide-d6 Carboxylic Acid is a deuterated compound of Enzalutamide Carboxylic Acid. Enzalutamide Carboxylic Acid has a CAS number of 1242137-15-0. Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .

HDAC-IN-4-d4 is a deuterated compound of HDAC-IN-4.

4-amino-N-(4-nitrophenyl)benzenesulfonamide-d4 is a deuterated compound of 4-amino-N-(4-nitrophenyl)benzenesulfonamide.

Succinic-2,2,3,3-d4 Acid is a deuterated compound of Succinic Acid. Succinic Acid has a CAS number of 110-15-6. Succinic acid is a water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent.

3-Methyl-2-quinoxalinecarboxylic Acid-d4 is a deuterated compound of 3-Methyl-2-quinoxalinecarboxylic Acid. 3-Methyl-2-quinoxalinecarboxylic Acid has a CAS number of 74003-63-7. 3-Methyl-2-quinoxalinecarboxylic acid has a wide range of applications in life science related research.

4-Aminobutyric acid-2,2,3,3,4,4-d6 is a deuterated compound of 4-Aminobutyric acid. 4-Aminobutyric acid has a CAS number of 56-12-2. 4-Aminobutyric acid is the most common inhibitory neurotransmitter in the central nervous system.

Docosanoic-7,7,8,8-d4 Acid is a deuterated compound of Docosanoic Acid. Docosanoic Acid has a CAS number of 112-85-6. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.

Phthalic acid, bis-isobutyl ester-d4 is a deuterated compound of Phthalic acid, bis-isobutyl ester. Phthalic acid, bis-isobutyl ester has a CAS number of 84-69-5. Dibutyl phthalate is a plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.

Lithocholic Acid-d4 is a deuterated compound of Lithocholic Acid. Lithocholic Acid has a CAS number of 434-13-9. Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.

4-Bromobenzoic acid-d4 is a deuterated compound of 4-Bromobenzoic acid. 4-Bromobenzoic acid has a CAS number of 586-76-5.

4-Bromochlorobenzene-d4 is a deuterated compound of 4-Bromochlorobenzene.

Bempedoic acid-d4 is a deuterated compound of Bempedoic acid. Bempedoic acid has a CAS number of 738606-46-7. ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid is a regulator of lipid and carbohydrate metabolism.

Chenodeoxycholic Acid-d4 is a deuterated compound of Chenodeoxycholic Acid.

Cholic acid-d4 is a deuterated compound of Cholic acid.

Tauroursodeoxycholic Acid-d4 Sodium Salt is a deuterated compound of Tauroursodeoxycholic Acid Sodium Salt. Tauroursodeoxycholic Acid Sodium Salt has a CAS number of 14605-22-2. Tauroursodeoxycholate, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.

Glycocholic acid-d4 is a deuterated compound of Glycocholic acid. Glycocholic acid has a CAS number of 475-31-0. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways.

4’-Hydroxy Diclofenac-d4 (Major) is a deuterated compound of 4’-Hydroxy Diclofenac. 4’-Hydroxy Diclofenac has a CAS number of 64118-84-9. 4'-Hydroxydiclofenac is a diclofenac metabolite.

4-Methylpentanoic-d11 acid is a deuterated compound of 4-Methylpentanoic acid. 4-Methylpentanoic acid has a CAS number of 646-07-1. 4-Methylpentanoic acid is a short-chain fatty acid (SCFA) and a metabolite of 20 alpha-hydroxycholesterol.

4’-Hydroxy Diclofenac-d4 is a deuterated compound of 4’-Hydroxy Diclofenac. 4’-Hydroxy Diclofenac has a CAS number of 64118-84-9. 4'-Hydroxydiclofenac is a diclofenac metabolite.

1, 14-tetradecanedioic-2, 2, 13, 13-d4 acid is a deuterated compound of 1, 14-tetradecanedioic acid. 1, 14-tetradecanedioic acid has a CAS number of 821-38-5. Tetradecanedioic acid is a C14 dicarboxylic acid.

Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively. Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1). It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice ......

Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L. Clofibric acid has been found in wastewater effluent.

1-Bromo-4-nitrobenzene-d4 is a deuterated compound of 1-Bromo-4-nitrobenzene.

3,4-Difluoro-4'-(trans-4-propylcyclohexyl)biphenyl-d4 is a deuterated compound of 3,4-Difluoro-4'-(trans-4-propylcyclohexyl)biphenyl. 3,4-Difluoro-4'-(trans-4-propylcyclohexyl)biphenyl has a CAS number of 85312-59-0.

3-Indoleacrylic acid-d4 is a deuterated compound of 3-Indoleacrylic acid. 3-Indoleacrylic acid has a CAS number of 1204-06-4. 3-Indoleacrylic acid is a metabolite of tryptophan produced by Peptostreptococcus species. 3-Indoleacrylic acid has a beneficial effect on intestinal epithelial barrier function and mitigates inflammatory responses by immune cells.

5-Hydroxy tryptophol β-D glucuronide-d4 is a deuterated compound of 5-Hydroxy tryptophol β-D glucuronide.

4-Pyridoxic Acid-d3 Hydrochloride is a deuterated compound of 4-Pyridoxic Acid Hydrochloride. 4-Pyridoxic Acid Hydrochloride has a CAS number of 62511-95-9.

3,4-Difluoro-4'-(cis-4-propylcyclohexyl)biphenyl-d4 is a deuterated compound of 3,4-Difluoro-4'-(cis-4-propylcyclohexyl)biphenyl.

DL-4-Hydroxy-3-methoxymandelic-d3 acid is a deuterated compound of DL-4-Hydroxy-3-methoxymandelic acid.

Glycoursodeoxycholic Acid-d4 is a deuterated compound of Glycoursodeoxycholic Acid. Glycoursodeoxycholic Acid has a CAS number of 64480-66-6. Glycoursodeoxycholic acid is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct, therefore, exist in a glycine conjugated form. Bile acids are steroid acids found predominantly in bile of mammals.

Isochenodeoxycholic Acid-d4 is a deuterated compound of Isochenodeoxycholic Acid. Isochenodeoxycholic Acid has a CAS number of 566-24-5.

4-n-Nonylphenol-2,3,5,6-d4, OD is a deuterated compound of 4-n-Nonylphenol. 4-n-Nonylphenol has a CAS number of 104-40-5.

4-Hydroxyphenylacetic Acid-d6 is a deuterated compound of 4-Hydroxyphenylacetic Acid. 4-Hydroxyphenylacetic Acid has a CAS number of 156-38-7. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2.

N-Nitroso-N-(methyl-d3)-4-aminobutyric Acid is a deuterated compound of N-Nitroso-N-(methyl)-4-aminobutyric Acid. N-Nitroso-N-(methyl)-4-aminobutyric Acid has a CAS number of 61445-55-4.

Terephthalic-d4 Acid is a deuterated compound of Terephthalic Acid. Terephthalic Acid has a CAS number of 100-21-0. Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.