ltas-in-1

LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg mL to 64 μg mL. LtaS-IN-1 inhibits strain E1630 and E1590 with MIC values of 0.5 μg mL.

LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S. aureus and S. epidermidis, exhibiting MIC90 values of 0.5 μg/mL and 1 μg/mL, respectively.