lup-20(29)-ene-3b,23-diol

Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.

20-O-Acetylingenol-3-angelate (Euphorbia factor Pe1) is a natural compound found in the leaves and stems of the plant Inga. It has a variety of biological activities including tumor growth inhibition, anti-inflammatory, antifungal and antioxidant effects.

2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine or synthetically produced.

3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.

Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.

Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including diabetes, cardiovascular disease, bloo

sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate is an organosulfur compound. It has been used as a model compound to study the effects of sulfur-containing compounds on enzymatic activities and metabolic pathways. It has also been used to study the effects of sulfur-containing compounds on the regulation of bacterial growth and gene expression.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol is a useful organic compound for research related to life sciences. The catalog number is T124827 and the CAS number is 466663-12-7.

3-Acetoxy-27-hydroxy-20(29)-lupen is an acetyl ester form of 3α, 27-Dihydroxylupen-20(29)-en-28-oic acid methyl ester, which is a topoisomerase II inhibitor.

3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity. Additionally, it demonstrates notable anti-tumor properties.

29-Nor-20-oxolupeol(3 beta-Hydroxy-30-norlupan-20-one) has growth inhibitory effects on HL-60 cells.

Drim-7-ene-11,12-diol acetonide is a natural product for research related to life sciences. The catalog number is TN3895 and the CAS number is 213552-47-7.

Dynorphin B-29 (Leumorphin) (pig) is a peptide that exhibits multifaceted receptor interactions within the brain and isolated tissue systems. This compound is utilized in the study of immunoreactions [1].

4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate is an α-arabinopyranosides analogue isolated from the aboveground parts of barley [1].

11alpha,12alpha-Epoxy-3beta,23-dihydroxy-30-norolean-20(29)-en-28,13beta-olide is a natural product from Paeonia lactiflora.

3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.

16β-Hydroperoxyalisol B 23-acetate, a natural product, is isolable from Alisma orientale [1].

'(12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-one is a naturally occurring compound isolated from Cladosporium microorganisms [1].'

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

Eudesm-4(15)-ene-3alpha,11-diol is a compound derived from Eudesm-4(15)-ene-3alpha,11-diol.

Quercetin-3-O-β-D-galactopyranosyl-(1→6)-β-D-glucopyranoside (compound 1), a flavonoid glycoside, is extractable from M. delavayi leaves [1].

25-O-Acetyl-7,8-didehydro-cimigenol-3-O-β-D-xylopyranoside is a cycloartane triterpenoid isolated from Cimicifuga acerina [1].

23-Acetylshengmanol 3-O-β-D-xylopyranoside (Acetylshengmanol xyloside), a 9,19-cyclolanostane type triterpenoid, is isolated from the roots of Actaea pachypoda [1].

'(Des-Bromo)-Neuropeptide B (1-23) (human)' is an agonist for orphan G-protein-coupled receptors, exhibiting a K i of 1.2 nM for GPR7 (NPBW1) and 341 nM for GPR8 (NPBW2) respectively [1].

29-Hydroxyfriedelan-3-one is a natural product of Euonymus, Celastraceae. The catalog number is TN2836 and the CAS number is 39903-21-4. 29-Hydroxyfriedelan-3-one can be used as a reference standard.

(2α,3β)-Olean-12-ene-2,3-diol (Compound 3) is a triterpenoid compound that possesses a lupane, oleanane, and ursane skeleton.

Lup-20(29)-ene-3bate,23-diol is a natural product from Cratoxylum formosum.

5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences. The catalog number is T67591 and the CAS number is 25961-11-9.

3(20)-Phytene-1,2-diol is a natural product of Helianthus, Asteraceae. The catalog number is TN2858 and the CAS number is 438536-34-6. 3(20)-Phytene-1,2-diol can be used as a reference standard.

DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1].

20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant platelet aggregation accompanied by induction of phosphorylation of PKC substrates in platelets,

20-oxopregna-5,14-dien-3-yl acetate is a useful organic compound for research related to life sciences and the catalog number is T131412.

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

20S,24R-Epoxydammar-12,25-diol-3-one is a natural product of Pseudolarix, Pinaceae. The catalog number is TN2803 and the CAS number is 25279-15-6. 20S,24R-Epoxydammar-12,25-diol-3-one can be used as a reference standard.

Quercetin 3-O-(6-O-malonyl)-b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T123838 and the CAS number is 96862-01-0.

1. Alisol B 23-acetate (Alisol B Acetate) produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. 2. Alisol B 23-acetate produces promotive effect on liver regeneration, due to FXR-mediated regulation of genes involved in hepatocyte proliferation and hepato-protection. 3. Alisol B 23-acetate produces a protective effect against CCl4-induced hepatotoxicity, due to FXR and STAT3-mediated gene regulation.

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.

MAO-B-IN-20 (Compound C14), a potent MAO-B inhibitor boasting an IC50 of 0.037 μM, demonstrates excellent metabolic stability and brain-blood barrier permeability. It holds potential for Parkinson's disease research [1].

3-Epimeliasenin B is a natural product for research related to life sciences. The catalog number is TN5953 and the CAS number is 1222475-77-5.

p-Menth-1-ene-3,6-diol is a natural product of Mentha, Lamiaceae. The catalog number is TN4728 and the CAS number is 4031-55-4. p-Menth-1-ene-3,6-diol can be used as a reference standard.

Cycloart-23-ene-3,25-diol has anti-inflammatory activity, it has protective activity against streptozotocin induced toxicity. Cycloart-23-ene-3,25-diol treatment can decrease liver malondialdehyde but increase superoxidase dismutase and reduced glutathion

3-(4-(2-Methoxyethyl)phenoxy)propane-1,2-diol is a useful organic compound for research related to life sciences and the catalog number is T64642.

threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol is a natural product for research related to life sciences. The catalog number is TN5142 and the CAS number is 848031-94-7.

1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.

Lup-20(29)-ene-2alpha,3beta-diol is a natural product of Oroxylum, Bignoniaceae. The catalog number is TN4460 and the CAS number is 61448-03-1. Lup-20(29)-ene-2alpha,3beta-diol can be used as a reference standard.

(S)-2-Amino-3-(benzo[b]thiophen-3-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66164 and the CAS number is 72120-71-9.

Nucleoside Derivatives –Fluoro-modified nucleosides, 6-Modified purine nucleosides, 3’-Modified nucleosides

hMAO-B-IN-3 (Compound 15) is a potent hMAO-B inhibitor (IC 50 = 47.4 nM) with favourable drug-like properties and a broad safety window. Therefore, hMAO-B-IN-3 is a suitable candidate for lead optimization and multitarget-directed ligands development [1].