m-peg3-sulfone-peg3-boc

m-PEG3-Sulfone-PEG3-Boc is a polyethylene glycol (PEG)-derived proteolysis-targeting chimera (PROTAC) linker used in the synthesis of PROTACs[1].

DSPE-PEG-OH (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.

Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.

Amine-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Amine-PEG-amine (MW 3400) is a polyethylene glycol (PEG) -based linker used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

NH2-PEG4-Lys(Boc)-NH-(m-PEG24) is a 28-unit polyethylene glycol (PEG) linker with a cleavable bond, frequently used in the production of antibody-drug conjugates (ADCs)[1].

m-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].

Acrylate-PEG-OH (MW 5000) is a Polyethylene Glycol (PEG)-based linker compound primarily utilized in PROTAC synthesis [1].

LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the CDK9 inhibitor, SNS 032, linked to a hydrophobic tag via a glycol linker. Notably, LL-K9-3 does not affect the degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). Tested in 22RV1 cells, it effectively reduces androgen receptor (AR) and cMyc expression by inducing the selective and synchronous degradation of CDK9 and cyclin T1.

3-Mercaptopropionic acid NHS ester is a useful organic compound for research related to life sciences and the catalog number is T64663.

Amine-PEG-thiol (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker primarily used for the synthesis of PROTACs[1].

Methyl 3-hydroxypropanoate is a PROTAC linker compound, which belongs to the alkyl ether family. It is commonly employed in the synthesis of PROTACs.

PROTAC BET Degrader-3 is a potent degrader of BET proteins based on the PROTAC (PROteolysis TArgeting Chimera) technology.

m-PEG3-Sulfone-PEG3-acid is a polyethylene glycol (PEG)-based linker used in protein degradation via targeted chimera (PROTAC) [1].

PROTAC SOS1 Degrader-3 is a potent agent specifically designed to target and degrade SOS1 via the ubiquitin-proteasome system [1].

Aminooxy-PEG-OH (MW 2000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1].

m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Amine-PEG-CH2COOH (MW 3400) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs).

Amine-PEG-amine (MW 35000), a PEG-based PROTAC linker, is utilized for the synthesis of PROTACs[1].

Thiol-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derivative frequently used in the construction of PROTACs, bifunctional compounds designed for targeted protein degradation [1].

m-PEG-triethoxysilane (MW 2000) is a polyethylene glycol (PEG)-based linker compound tailored for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Mal-PEG-mal (MW 3400) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system in cells.

m-PEG-Lys-NHS ester (MW 20,000) is an alkyl ether-based PROTAC linker commonly used in PROTAC synthesis[1].

Biotin-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker used in the synthesis of PROTACs[1].

m-PEG-acrylate (MW 2000) is a polyethylene glycol (PEG) derivative linker that plays a crucial role in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

m-PEG-triethoxysilane (MW 1000) is a triethoxysilane-functionalized polyethylene glycol (PEG) derivative that serves as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs), which are compounds used for targeted protein degradation[1].

m-PEG12-Boc, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl-modified triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand utilized in the synthesis of GalNAc-lysosome-targeting chimeras (LYTACs). These chimeras facilitate targeted protein degradation through engagement with the asialoglycoprotein receptor [1].

m-PEG-NH2 (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC EGFR Degrader 3, a highly potent molecule, exhibits remarkable cellular activity against H1975 and HCC827 cells, maintaining high selectivity. It additionally reveals the lysosome's crucial role in the degradation mechanism of mutant EGFR [1].

Azide-PEG-azide (MW 20000) is a polyethylene glycol (PEG)-based linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Boc-PEG4-sulfone-PEG4-Boc is a polyethylene glycol (PEG)-derived linker developed for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1].

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).

Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) linker compound, designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].

VH 032 linker 3 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 . N/A

m-PEG4-Boc is a cleavable 4-unit polyethylene glycol (PEG) linker widely employed in the synthesis of antibody-drug conjugates (ADCs) [1] and serves as a PEG-based PROTAC linker for the synthesis of PROTACs [2].

m-PEG-Tresyl (MW 5000) is a polyethylene glycol (PEG)-based linker used in proteolysis-targeting chimeras (PROTACs), facilitating the joining of two essential ligands necessary for forming PROTAC molecules. This linker promotes selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Boc-NH-PEG-amine (MW 5000) is a PEG-based PROTAC linker used for the synthesis of PROTACs [1].

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-derived PROTAC linker used for synthesizing PROTACs [1].

Carboxymethyl-PEG-Carboxymethyl (MW 5000) is a polyethylene glycol (PEG)-based linker designed specifically for the synthesis of PROTACs [1].

1-(t-Boc-Aminooxy)-3-aminooxy-propane is an alkyl ether-based PROTAC linker used in the synthesis of PROTACs [1].

m-PEG-mal (MW 5000) is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-PEG-Succinimidyl Valerate (MW 20000) is a polyethylene glycol (PEG)-based linker with a molecular weight of 20000, crucial for synthesizing proteolysis targeting chimeras (PROTACs).

3-Maleimidopropionic acid, an alkyl chain-derived PROTAC linker, is used in PROTAC synthesis[1].

m-PEG-NPC (MW 20000) is a PEG-based linker for PROTACs, joining two essential ligands to facilitate the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Fmoc-azetidine-3-carboxylic acid is a valuable compound for life sciences research (catalog number: T65634, CAS number: 193693-64-0).

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].