mal-peg2-acid

Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It can be conjugated to Tubulysin and its derivative cytotoxic molecule [1].

N-Mal-N-bis(PEG2-acid) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system in cells.

Mal-amido-PEG2-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands to form PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Mal-PEG-mal (MW 3400) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system in cells.

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

The compound 3,4-Dibromo-Mal-PEG8-acid is a PEG-based PROTAC linker employed for PROTAC synthesis[1].

Mal-N-bis(PEG4-C2-acid) is a polyethylene glycol (PEG) derivative used as a PEG-based PROTAC linker for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Mal-PEG1-acid is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

HO-PEG-mal (MW 3400) is a PEG-based linker for PROTACs, joining two essential ligands necessary for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-Mal-Lysine-PEG4-acid is a PEG-based PROTAC linker used for PROTAC synthesis [1].

Mal-PEG-Succinimidyl Valerate (MW 20000) is a polyethylene glycol (PEG)-based linker with a molecular weight of 20000, crucial for synthesizing proteolysis targeting chimeras (PROTACs).

m-PEG-mal (MW 5000) is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-derived PROTAC linker used for synthesizing PROTACs [1].

Mal-amido-PEG12-acid is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by connecting two essential ligands and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-amido-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

m-PEG-mal (MW 20000) is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-amido-PEG24-acid is a PEG-based linker for PROTACs that joins two essential ligands, critical for the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG-mal (MW 2000) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-PEG12-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-PEG10-acid is a PEG-based linker used in PROTACs, facilitating the combination of two key ligands essential for PROTAC molecule formation. This linker aids in selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Mal-PEG5-acid is a PEG-based linker for PROTACs, joining two essential ligands essential for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in the synthesis of PROTACs[1].

2-Bromo-22-dimethyl-acetamido-PEG3-acid is a polyethylene glycol (PEG) derivative commonly used as a PEG-based PROTAC linker in PROTAC synthesis [1].

Mal-amido-PEG16-acid is a PEG-based linker used in PROTAC molecules, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-amido-PEG9-acid is a PEG-based linker for PROTACs, crucial for joining two essential ligands and facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-PEG3-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, [Biomedical applications]. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(R)-Azetidine-2-carboxylic acid, with catalog number T66331 and CAS number 7729-30-8, is a valuable organic compound for life sciences research.

Mal-PEG8-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG-mal (MW 10000) is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-NH-ethyl-SS-propionic acid, a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1], plays a crucial role in the modulation of drug release from the conjugate.

Mal-amido-PEG8-C2-acid (US2018339985, example 142) is a noncleavable linker for antibody-drug conjugates (ADCs) [1].

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

Mal-PEG6-acid, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-PEG6-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG-mal (MW 2000) is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

HO-PEG-mal (MW 5000) is a PEG-based linker for PROTACs that connects two essential ligands necessary for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system in cells.

Mal-PEG24-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-(CH2COOH)2, also known as compound 7a, is an intermediate compound that contains maleimidoethyl for use in hydrophilic ADC linker synthesis[1].

m-PEG-mal (MW 30000) is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG-mal (MW 5000) is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.