malonyl coenzyme a lithium

Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.

β-Methylcrotonyl coenzyme A lithium, a key intermediate in leucine metabolism, serves as a substrate to investigate the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) [1].

Glutaryl coenzyme A lithium, a derivative of the endogenous metabolite glutaryl coenzyme A, is utilized in experiments related to HMG-CoA or glutaryl-CoA.

Acetyl-coenzyme A (Acetyl-CoA) lithium, a membrane-impermeant central metabolic intermediate, is integral to the TCA cycle and oxidative phosphorylation. It regulates cellular mechanisms by serving as the sole donor of acetyl groups for post-translational acetylation of proteins and is a critical precursor in lipid synthesis [1] [2] [3] [4].

Octanoyl coenzyme A lithium is a derivative of the fatty acid acyl coenzyme A. Octanoyl coenzyme A lithium inhibits citrate synthase and glutamate dehydrogenase (IC50: 0.4-1.6 mM).

Palmitoyl coenzyme A lithium, an acyl-CoA thioester, facilitates transport into the mitochondrial matrix through the carnitine shuttle system for β-oxidation. Additionally, it serves as a substrate in sphingosine biosynthesis [1] [2].

DL-β-Hydroxybutyryl coenzyme A lithium, an intermediate in butyric acid fermentation and lysine and tryptophan metabolism, is synthesized from β-hydroxybutyric acid by short-chain-CoA synthase [1] [2].

Arachidonoyl coenzyme A lithium, an unsaturated fatty acyl coenzyme A derivative, results from the condensation of coenzyme A's thiol group with arachidonic acid's carboxyl group [1].

Oleoyl coenzyme A (Oleoyl-CoA) lithium, a thioester derived from oleic acid and coenzyme A, functions as a metabolite in both Escherichia coli and mice [1] [2].

Lauroyl coenzyme A lithium salt is a kind of coenzyme A. Coenzyme A acts as an acyl carrier, namely acetyl-CoA. Lauryl-CoA (C12-CoA) is a long-chain (C-12) saturated fatty acyl-CoA that functions as an intermediate in lipid metabolism, involved in lipid biosynthesis and fatty acid transport. Lauroyl-CoA is a substrate for the FAM34A protein and the product of firefly luciferase.

Myristoyl coenzyme A lithium, a compound marked by lithium in its myristoylated form, plays a crucial role in the biochemical mechanism of myristoylation, essential for both viral functionalities and tumor growth in colon epithelial cells. This process is predominantly governed by N-myristoyltransferase (NMT), which exhibits increased activity in colon epithelial tumors compared to normal cells. The activity of NMT is significantly influenced by the reduction of coenzyme A (CoA), a vital regulator that enhances NMT's ability to induce myristoylation, unlike its oxidized form which impedes this process. Consequently, Myristoyl coenzyme A serves as an inhibitor to the demyristoylation activity, showcasing its potential as an anticancer and antiviral agent.