mark-in-1

MARK-IN-1 is a potent inhibitor of microtubule affinity regulating kinase (MARK) with an IC50 of less than 0.25 nM.

MARK-IN-4, a potent inhibitor of microtubule affinity-regulated kinase (MARK) (IC50: 1 nM), presents a promising strategy for blocking neurofibrillary tangles in Alzheimer's disease.

IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research [1].