methyl 2 (7 hydroxy 2 oxo 2h chromen 4 yl)acetate

2,5-Dioxopyrrolidin-1-yl 2-(7-hydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetate is a useful organic compound for research related to life sciences. The catalog number is T67683 and the CAS number is 96735-88-5.

2-NBDG is a fluorescent indicator for direct glucose uptake measurement. It is an indicator of cell viability.

6-Ethyl-7-hydroxy-4-methylchromen-2-one is a fluorescent dye.

Hoechst 34580 xHCl(23555-00-2(free base) is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.

2-(4-Hydroxyphenylazo)benzoicacid is a spectrophotometric probe that shows changes in absorption spectra upon binding to proteins and binds to bovine serum proteins.

C.I. Vat Yellow 2 (Calcoloid Yellow GCD) is a yellow dye agent that can also be used to detect adsorption behavior on natural sediments.

Rhod-2 AM is a fluorescent probe of the mitochondrion with λex of 552 nm and λem of 581 nm.

SBP-2, a sulfite bioluminescent probe (SBP), detects sulfite through a mechanism involving sulfite-mediated intramolecular cleavage [1].

2-Aminoacridone is a widely used fluorophore (λexc=428 nm, λem=525 nm).

7-Acetoxy-4-bromomethylcoumarin serves as a fluorescent label for fatty acids.

1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine, featuring a phosphatidylethanolamine head group, serves as a fluorescent probe to assess surface lipid oxidation in lipoproteins and plasma [1].

2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.

Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells. It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells.

NIR-βgal-2, a highly sensitive β-galactosidase-activated near-infrared fluorescent probe, facilitates the visualization of β-galactosidase in breast cancer [1].

4-(Benzyloxy)-2-nitrophenol serves as a synthetic precursor for constructing fluorescent ion indicators [1].

1,3-Di-(2-pyrenyl)propane, a fluorescent indicator, is utilized to monitor the fluidity of bacterial membrane lipids through intramolecular excimerization and exhibits temperature-dependent fluorescence lifetime distributions [1] [2].

Rhod-2 (potassium salt) is a water-soluble, red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon calcium binding (ex max = 549 nm; calcium-free v. ex/em max = 552/581 nm; calcium-bound). Unlike the UV-excitable indicators fura-2 and indo-1 , there is no accompanying spectral shift.

5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2’,7’,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production. 1.Hempel, S.L., Buettner, G.R., O’Malley, Y.Q., et al.Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2’,7’-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2’,7’-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123Free Radic. Biol. Med.27(1-2)146-159(1999)

N-(2-hydroxyethyl)-Naphthalimide is a fluorescent probe for nucleic acid detection whose fluorescence can be burst.

N-[4-(2-Benzimidazolyl)phenyl]maleimide serves as a potent fluorescent probe featuring an excitation maximum at 315 nm and emission maximum at 360 nm, suitable for the fluorometry of thiol compounds [1].

9-Amino-6-chloro-2-methoxyacridine serves as a pH-sensitive fluorescent probe commonly utilized to assess vacuolar pH variations upon substrate translocation across the tonoplast via a putative H+/solute antiport system [1].

Ru(bpy)2(dcbpy)NHS dihexafluorophosphate, when coupled with gold nanoparticle amplification, serves as a method for lysozyme detection via electrochemiluminescence [1].

Pyridine-2-carboxaldehyde 4-nitrophenylhydrazone (PCNPH) serves as a chromogenic substrate for peroxidase enzymes, reacting to form a purple indamine dye in the presence of peroxidases and peroxides [1].

N-(2-Hydroxyethyl)-2-phenylacetamide is a fluorescent dye [1].

Potassium 2-naphthylamine-6,8-disulfonic acid is a chemical compound utilized in the synthesis of dyes, pharmaceuticals, and agricultural chemicals [1].

4-Hydrazino-7-nitrobenzofurazan hydrazine adduct serves as a fluorescent reagent for protein labeling.

4-(2-Aminoethylamino)-7-(N,N-dimethylsulfamoyl)benzofurazan serves as a precolumn fluorescence derivatization reagent.

Fura-2 AM is an indicator of ratiometric fluorescent Ca2+.

Bis[3,4,6-trichloro-2-(pentyloxycarbonyl)phenyl] oxalate is a fluorescent dye capable of chemiluminescence generation [1].

3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin serves as a pteridine-based fluorescent guanosine analogue and DNA uptake tracer utilized extensively for investigation into DNA binding and dynamics. It exhibits an absorbance peak at 350 nm and a corresponding emission peak at 430 nm [1].

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.

Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells. [1] It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells.

Quin-2 is a high-affinity fluorescent calcium indicator (Kd = 115 nM for calcium). It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation/emission maxima for quin-2 are 339 and 492 nm, respectively.

2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate (ε-dATP), a fluorescent derivative of 2’-deoxyadenosine-5’-O-triphosphate (dATP), promotes sister chromatid exchange in stimulated primary mouse spleen T- and B lymphocytes with LPS or concanavalin A at concentrations of 50 to 150 µM. Utilized in ambiguous base pairing investigations within vinyl chloride-induced mutagenesis research, ε-dATP, along with its related compound ε-ATP—which exhibits an emission peak at 415 nm after being excited at 300 nm—contributes to understanding genetic alterations mechanisms.

Mag-Fura-2 AM, a cell-permeable fluorescent compound, serves as a selective indicator for magnesium ions (Mg2+), demonstrating significant preference for Mg2+ over other bivalent ions including zinc (Zn2+), copper (Cu2+), and calcium (Ca2+). It notably exhibits over 13,000-fold greater selectivity for Mg2+ compared to Ca2+ (Mg2+Kd = 1.9 nM vs. Ca2+Kd = 25 μM). The excitation and emission peak wavelengths are 369 nm and 511 nm, respectively. Further, Mag-Fura-2 AM is utilized as an indirect measure of ATP consumption or production due to its magnesium ion sensitivity.

ING-2 AM is a membrane-permeable fluorescent indicator specifically designed for sodium ions (Na+), exhibiting a binding affinity with a dissociation constant (Kd) of 20 mM. With excitation and emission maxima (λ) at 525 nm and 545 nm respectively, this compound achieves a 20-fold selectivity over potassium ions (K+). It is utilized both in vitro and in situ to monitor real-time sodium influx.

Flutax-2 (5/6-mixture), an active fluorescent derivative of paclitaxel, binds to polymerized α,β tubulin dimers, with an excitation/emission wavelength of 496/524 nm. Derived from paclitaxel, a diterpenoid secondary metabolite from Taxus species utilized in various cancer research [1], it requires storage protection from light.

7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b), a fluorescent hydroxylated derivative, serves as a probe for detecting hydroxyl radicals associated with DNA damage [1]. For preservation, it should be protected from light.

2-([1,1-Biphenyl]-4-yl)-5-phenyl-1,3,4-oxadiazole is a useful organic compound for research related to life sciences. The catalog number is T66233 and the CAS number is 852-38-0.

1-Methyl-7-nitroisatoic anhydride (1M7) is a reagent. It detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.

CI Direct Brown 2 is a direct dye. It is soluble in water and ionizable to form colored anions. It also can directly dye cellulose fibers or protein fibers.

Sodium 4-(3-(4-hydroxy-5-isopropyl-2-methylphenyl)-1,1-dioxido-3H-benzo[c][1,2]oxathiol-3-yl)-2-isopropyl-5-methylphenolate is a useful organic compound for research related to life sciences. The catalog number is T66669 and the CAS number is 62625-21-2.

GNF-2-PEG-acid is usually used as a fluorescent probe.

C.I. Solvent Orange 2 is an agent of dye.

2-Aminobenzamide is a neutral and stable compound used as a fluorescent tag, numerously in Glycan analysis. It acts as the starting material for several important reactions.

Hoechst 33258 analog 2 is part of a family of blue fluorescent dyes used to stain DNA.

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye that serves as an effective quencher for quantum dots (QDs) fluorescence and as a capture probe for the virus antigen EV71. Additionally, it can be utilized as a sensitive label for electrogenerated chemiluminescence (ECL) detection of matrix metalloproteinases (MMPs) [1] [2] [3].

8-(2-azidobenzylthio) NAD+ is a derivatized version of NAD+, a signaling molecule and enzyme cofactor, featuring an azido group (azidobenzylthio) that enables click chemistry applications.

Hoechst 33342 analog 2 is an analog of Hoechst 33342 which is a DNA minor groove binder.

AMCA-X, N-succinimidyl ester is an amine-reactive, UV-excitable, blue fluroscent dye.