methylamino peg1 acid

Methylamino-PEG1-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands crucial for PROTAC molecule formation and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)

Methylamino-PEG1-Boc is a PEG-based linker for PROTACs, which connects two essential ligands essential for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

Methylamino-PEG3-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands crucial for PROTAC molecule formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker frequently utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Bis-PEG1-acid is a PEG-based linker for PROTACs [PROteolysis TArgeting Chimeras] that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Azido-PEG1-C2-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system [within cells].

Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Hydroxy-PEG1-acid is a non-cleavable 1-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Acid-PEG1-C2-Boc is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Fmoc-NH-PEG1-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for forming PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system in cells.

1-Boc-azetidine-3-carboxylic acid is a valuable organic compound for life sciences research (catalog number T67359, CAS number 142253-55-2).

Mal-PEG1-acid is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

Amino-PEG1-C2-acid is a PEG-based linker used in PROTACs to conjugate two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Methylamino-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands critical for PROTAC molecule formation, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tri-(PEG1-C2-acid) is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Methylamino-PEG2-acid is a PEG-based linker for PROTACs, joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

1-Cbz-azetidine-3-carboxylic acid (catalog number: T66609, CAS number: 97628-92-7) is a valuable organic compound for life sciences research.

Bromo-PEG1-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, and facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in the synthesis of PROTACs[1].

Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].