methylamino peg4 acid

Methylamino-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands critical for PROTAC molecule formation, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

Benzyloxy carbonyl-PEG4-acid is a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines with the help of activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis.

Carboxy-PEG4-sulfonic acid is a PEG-based linker frequently used in PROTAC synthesis [1].

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker incorporating biotin for labeling, making it a versatile tool in PROTAC synthesis[1].

DBCO-PEG4-C2-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group, primarily used in PROTAC synthesis [1].

Acid-C2-PEG4-C2-NHS ester, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Bis-PEG4-acid is a PEG PROTAC linker (PROteolysis TArgeting Chimera) used in targeted protein degradation applications.

Acid-PEG4-S-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules and enables selective protein degradation through the ubiquitin-proteasome system within cells.

(S)-TCO-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands critical for PROTAC molecule formation, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG4-C2-acid, a PEG-based PROTAC linker, is utilized in the synthesis of vRucaparib-TP4. It serves as a non-cleavable 4 unit PEG ADC linker for antibody-drug conjugate (ADC) synthesis.

m-PEG4-C6-phosphonic acid ethyl ester, a polyethylene glycol (PEG)-based linker compound, is used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Benzyl-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for PROTAC molecule formation, thereby enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG4-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands crucial for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Mal-N-bis(PEG4-C2-acid) is a polyethylene glycol (PEG) derivative used as a PEG-based PROTAC linker for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Propargyl-PEG4-Sulfone-PEG4-acid serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

N-(Azido-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG) derived PROTAC linker, facilitating PROTAC synthesis [1].

DBCO-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Cl-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG4-S-PEG4-acid, a polyethylene glycol (PEG)-based PROTAC linker, is suitable for synthesizing Proteolysis Targeting Chimera (PROTACs) [1].

N-Biotin-N-bis(PEG4-acid) is a polyethylene glycol (PEG) derived PROTAC linker used for the synthesis of PROTACs [1].

Mal-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-Methyl-4-(methyldisulfanyl)pentanoic acid is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and is designed to be cleavable.

Carboxy-PEG4-phosphonic acid, a polyethylene glycol (PEG)-derived linker, is utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Acid-PEG4-mono-methyl ester, a PEG- and Alkyl ether-based PROTAC linker, can be employed for PROTAC synthesis[1].

Bromo-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules and facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Boc-PEG4-phosphonic acid ethyl ester is a polyethylene glycol (PEG) derived linker compound used in the synthesis of PROteolysis TArgeting Chimeras (PROTACs) [1].

N-(m-PEG4)-N'-(PEG2-acid)-Cy5 is a polyethylene glycol (PEG)-derived linker compound utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs) [1].

N-(Biotin-PEG4)-N-bis(PEG4-acid) HCl salt is a PEG Linker which may be useful in the development of antibody drug conjugates.

N-(Azido-PEG3)-N-bis(PEG4-acid) is a polyethylene glycol-based linker, designed for the synthesis of PROTACs [1].

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker compound primarily used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Lipoamido-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Carboxy-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker used in the synthesis of PROTACs, serving as an integral compound [1].

Thiol-C9-PEG4-acid is a PEG-based linker for PROTACs that facilitates the conjugation of two essential ligands, playing a crucial role in the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

4-Boc-amino-22-dimethylbutyric acid is an alkyl ether-derived PROTAC linker, suitable for PROTAC synthesis.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

m-PEG4-sulfonic acid is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Boc-aminoxy-PEG4-acid is a PEG-based linker for PROTACs, designed to connect two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-Bromobutylphosphonic acid is an alkyl chain-derived PROTAC linker used for the synthesis of PROTACs [1].

Methylamino-PEG4-Boc is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands critical for producing PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl ether-based linker suitable for PROTAC synthesis [1].

Boc-PEG4-sulfonic acid is a PEG-based linker for PROTACs, facilitating the connection between two essential ligands necessary for PROTAC molecule formation, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells[1].

Fmoc-aminooxy-PEG4-acid is a PEG-based linker compound used in PROTAC synthesis [1].

Sulfone-Bis-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG3-Sulfone-PEG4-acid, a polyethylene glycol (PEG) derivative, is frequently employed as a linker in the construction of proteolysis targeting chimeras (PROTACs) [1].