methylmalonyl-coenzyme a

Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathwaySci. Prog.94(Pt 2)109-137(2011) 2.Tabita, F.R.The hydroxypropionate pathway of CO2 fixation: Fait accompliProc. Natl. Acad. Sci. U.S.A.106(50)21015-21016(2009) 3.Medicine, I.o.Vitamin B12Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline306-356(1998) 4.Cardinale, G.J., Carty, T.J., and Abeles, R.H.Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B12 deficiency, on fatty acid synthesisJ. Biol. Chem.245(15)3771-3775(1970)

Methylmalonyl-CoA tetralithium, also known as Methylmalonyl coenzyme A, serves as a metabolic byproduct derived from the breakdown of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. It is converted into succinyl-CoA through the enzymatic activity of methylmalonyl-CoA mutase (MCM) in the presence of the coenzyme vitamin B12 [1].

dimethyl 2-(methyl-d3)malonate is a deuterated compound of dimethyl 2-(methyl)malonate. dimethyl 2-(methyl)malonate has a CAS number of 516-05-2. Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A. It is an indicator of Vitamin B-12 deficiency in cancer.

2-Methylpropanedioic acid-d3 is a deuterated compound of 2-Methylpropanedioic acid. 2-Methylpropanedioic acid has a CAS number of 516-05-2. Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A. It is an indicator of Vitamin B-12 deficiency in cancer.