migraine headache

Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.

Frovatriptan is a highly potent agonist of the 5-HT 1B//D receptors, exhibiting the highest potency among triptan compounds. It possesses prominent cerebroselectivity. Frovatriptan demonstrates efficacy and even superiority in certain endpoints, including when administered during the headache phase of migraine attacks accompanied by aura [1].

RI 61 (sumatriptan succinate) is utilized in the therapy of migraine, cluster headaches, new daily persistent headache, and cyclic vomiting syndrome.

Sumatriptan (GR 43175) hydrochloride can be used in the research of migraine headache that is an orally active agonist of 5-HT1 receptor. The Ki values of Sumatriptan hydrochloride against 5-HT1D, 5-HT1B and 5-HT1A receptors are 17 nM, 27 nM and 100 nM, respectively. [1] [2].